DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn42Da and Serpinb6a

DIOPT Version :9

Sequence 1:	NP_524955.2	Gene:	Spn42Da / 49805	FlyBaseID:	FBgn0265137	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_001157589.1	Gene:	Serpinb6a / 20719	MGIID:	103123	Length:	399	Species:	Mus musculus

Alignment Length:	402	Identity:	131/402 - (32%)
Similarity:	202/402 - (50%)	Gaps:	35/402 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 GCWLLPLLGLALFPFPPVHTADVTMADAAHQEFARRLALFSINVYGKLSGQKPGENIVFSPFSIQ 73
            ||...| .|..|....|:..|:.|               |::|:. |:.|:...:|:..||.||.
Mouse     9 GCCAGP-RGYRLTIMDPLQEANGT---------------FALNLL-KILGEDSSKNVFLSPMSIS 56

  Fly    74 TCAAMARLGAENETATQLDQGLGL---ASSDPEQIAHSFHQVLAAYQDS---QILRIANKIFVMD 132
            :..||..:||:..||:|:.|.|.|   :.:....:...|..:|.....:   .:||.||::|...
Mouse    57 SALAMVFMGAKGTTASQMAQALALDKCSGNGGGDVHQGFQSLLTEVNKTGTQYLLRTANRLFGDK 121

  Fly   133 GYQLRQEFDQLLSKQFLSAAQSVDF-SKNVQAAATINNWVEQRTNHLIKDLVPADVLNSESRLVL 196
            ...|...|.....|.:.:..:.:|| ....::...||.||.::|...||:::....:||::.|||
Mouse   122 TCDLLASFKDSCLKFYEAELEELDFQGATEESRQHINTWVAKKTEDKIKEVLSPGTVNSDTSLVL 186

  Fly   197 VNAIHFKGTWQHQFAKHLTRPDTFHLDGERTVQVPMMSLKERFRYADLPALDAMALELPYKDSDL 261
            ||||:|||.|:.||.|..||...|.:.......|.||..|..|:...:..:....|.|||..|:|
Mouse   187 VNAIYFKGNWEKQFNKEHTREMPFKVSKNEEKPVQMMFKKSTFKMTYIGEIFTKILLLPYVSSEL 251

  Fly   262 SMLIVLPNTKTGLPALEEKLRLTTLSQITQ--SLYETKVALKLPRFKAEFQVELSEVFQKLGMSR 324
            :|:|:||:....|..:|:::......:.|:  .:.|.:|.:.||:||.|....:::...||||:.
Mouse   252 NMIIMLPDEHVELSTVEKEVTYEKFIEWTRLDKMDEEEVEVFLPKFKLEENYNMNDALYKLGMTD 316

  Fly   325 MFSDQAEFGKMLQSPEPLKVSAIIHKAFIEVNEEGTEAAAATG--MAVRRKRAIMSPEEPIEFFA 387
            .|..:|:|..| .|.:.|.:|.::||||:|||||||||||||.  |.||..|  .:|    .|.|
Mouse   317 AFGGRADFSGM-SSKQGLFLSKVVHKAFVEVNEEGTEAAAATAGMMTVRCMR--FTP----RFCA 374

  Fly   388 DHPFTYVLVHQK 399
            ||||.:.:.|.|
Mouse   375 DHPFLFFIHHVK 386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn42Da	NP_524955.2	SERPIN	45..408	CDD:238101	123/366 (34%)
Serpinb6a	NP_001157589.1	SERPIN	25..399	CDD:294093	125/385 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BBFJ
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	1	1.000	-	-		otm44262
orthoMCL	1	0.900	-	-		OOG6_100128
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.730