DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spn42Da and Serpina1b

DIOPT Version :9

Sequence 1:	NP_524955.2	Gene:	Spn42Da / 49805	FlyBaseID:	FBgn0265137	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_033270.3	Gene:	Serpina1b / 20701	MGIID:	891970	Length:	413	Species:	Mus musculus

Alignment Length:	419	Identity:	131/419 - (31%)
Similarity:	202/419 - (48%)	Gaps:	25/419 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LVPCGCW-LLPLLGLAL----FPFPPVHTADVTMAD---AAHQEFARRLALFSINVYGKLSGQKP 61
            :.|...| ||.|.||..    |....|...|.:..|   |:| |.|..|..|:|::|.:|..|..
Mouse     1 MTPSISWGLLLLAGLCCMVPSFLAEDVQETDTSQKDQSPASH-EIATNLGDFAISLYRELVHQSN 64

  Fly    62 GENIVFSPFSIQTCAAMARLGAENETATQLDQGL--GLASSDPEQIAHSFHQVLAAYQ--DSQI- 121
            ..||.|||.||.|..||..||::.:|.||:.:||  .|..:....|..||..:|....  ||::
Mouse    65 TSNIFFSPVSIATAFAMLSLGSKGDTHTQILEGLQFNLTQTSEADIHKSFQHLLQTLNRPDSELQ 129

  Fly   122 LRIANKIFVMDGYQLRQEFDQLLSKQFLSAAQSVDFSKNVQAAATINNWVEQRTNHLIKDLVPAD 186
            |...|.:||.:..:|.::|.:.....:.:...||:|:::.:|...||::||:.|...|.:.|..
Mouse   130 LSTGNGLFVNNDLKLVEKFLEEAKNHYQAEVFSVNFAESEEAKKVINDFVEKGTQGKIVEAVKE- 193

  Fly   187 VLNSESRLVLVNAIHFKGTWQHQFAKHLTRPDTFHLDGERTVQVPMMSLKERFRYADLPALDAMA 251
             |:.::...|.|.|.|||.|:..|....|....||:|...||:||||.|...........|.:..
Mouse   194 -LDQDTVFALANYILFKGKWKKPFDPENTEEAEFHVDKSTTVKVPMMMLSGMLDVHHCSILSSWV 257

  Fly   252 LELPYKDSDLSMLIVLPNTKTGLPALEEKLRLTTLSQITQSLYETKVALKLPRFKAEFQVELSEV 316
            |.:.|. .:.|.:.:||.... :..||:.|....:|:|..:.....|.:.:||........|..:
Mouse   258 LLMDYA-GNASAVFLLPEDGK-MQHLEQTLNKELISKILLNRRRRLVQIHIPRLSISGDYNLKTL 320

  Fly   317 FQKLGMSRMFSDQAEFGKMLQSPEPLKVSAIIHKAFIEVNEEGTEAAAATGMAVRRKRAIMSPEE 381
            ...||::|:|::.|:...:.:...|||:|..:|||.:.::|.||||||||..     .|:.....
Mouse   321 MSPLGITRIFNNGADLSGITEENAPLKLSKAVHKAVLTIDETGTEAAAATVF-----EAVPMSMP 380

  Fly   382 PIEFFADHPFTYVLVHQ-KDLPLFWGSVV 409
            ||..| ||||.:::..: ...|:|.|.||
Mouse   381 PILRF-DHPFLFIIFEEHTQSPIFVGKVV 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn42Da	NP_524955.2	SERPIN	45..408	CDD:238101	114/368 (31%)
Serpina1b	NP_033270.3	SERPIN	53..410	CDD:214513	114/366 (31%)
Serpina1b	NP_033270.3	RCL	368..387		7/24 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010