DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn42Da and Serpina1a

DIOPT Version :9

Sequence 1:	NP_524955.2	Gene:	Spn42Da / 49805	FlyBaseID:	FBgn0265137	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_001239498.1	Gene:	Serpina1a / 20700	MGIID:	891971	Length:	436	Species:	Mus musculus

Alignment Length:	421	Identity:	125/421 - (29%)
Similarity:	204/421 - (48%)	Gaps:	25/421 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 YRLVPCGCW-LLPLLGLAL----FPFPPVHTADVTMAD---AAHQEFARRLALFSINVYGKLSGQ 59
            :::.|...| ||.|.||..    |....|...|.:..|   |:| |.|..|..|:|::|.:|..|
Mouse    22 WKMTPSISWGLLLLAGLCCLVPSFLAEDVQETDTSQKDQSPASH-EIATNLGDFAISLYRELVHQ 85

  Fly    60 KPGENIVFSPFSIQTCAAMARLGAENETATQLDQGL--GLASSDPEQIAHSFHQVLAAYQ--DSQ 120
            ....||.|||.||.|..||..||::.:|.||:.:||  .|..:....|..||..:|....  ||:
Mouse    86 SNTSNIFFSPVSIATAFAMLSLGSKGDTHTQILEGLQFNLTQTSEADIHKSFQHLLQTLNRPDSE 150

  Fly   121 I-LRIANKIFVMDGYQLRQEFDQLLSKQFLSAAQSVDFSKNVQAAATINNWVEQRTNHLIKDLVP 184
            : |...|.:||.:..:|.::|.:.....:.:...||:|:::.:|...||::||:.|...|.:.|.
Mouse   151 LQLSTGNGLFVNNDLKLVEKFLEEAKNHYQAEVFSVNFAESEEAKKVINDFVEKGTQGKIAEAVK 215

  Fly   185 ADVLNSESRLVLVNAIHFKGTWQHQFAKHLTRPDTFHLDGERTVQVPMMSLKERFRYADLPALDA 249
            .  |:.::...|.|.|.|||.|:..|....|....||:|...||:||||:|...........|.:
Mouse   216 K--LDQDTVFALANYILFKGKWKKPFDPENTEEAEFHVDESTTVKVPMMTLSGMLHVHHCSTLSS 278

  Fly   250 MALELPYKDSDLSMLIVLPNTKTGLPALEEKLRLTTLSQITQSLYETKVALKLPRFKAEFQVELS 314
            ..|.:.|..:..::.::..:.|  :..||:.|....:|:...:.......:..||.....:..|.
Mouse   279 WVLLMDYAGNATAVFLLPDDGK--MQHLEQTLSKELISKFLLNRRRRLAQIHFPRLSISGEYNLK 341

  Fly   315 EVFQKLGMSRMFSDQAEFGKMLQSPEPLKVSAIIHKAFIEVNEEGTEAAAATGMAVRRKRAIMSP 379
            .:...||::|:|::.|:...:.:...|||:|..:|||.:.::|.||||||.|.:     :.:...
Mouse   342 TLMSPLGITRIFNNGADLSGITEENAPLKLSQAVHKAVLTIDETGTEAAAVTVL-----QMVPMS 401

  Fly   380 EEPIEFFADHPFTYVLVHQ-KDLPLFWGSVV 409
            ..||..| ||||.:::..: ...|:|.|.||
Mouse   402 MPPILRF-DHPFLFIIFEEHTQSPIFLGKVV 431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn42Da	NP_524955.2	SERPIN	45..408	CDD:238101	108/368 (29%)
Serpina1a	NP_001239498.1	SERPIN	76..433	CDD:214513	108/366 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010