DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn42Da and Serpinf2

DIOPT Version :9

Sequence 1:	NP_524955.2	Gene:	Spn42Da / 49805	FlyBaseID:	FBgn0265137	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_032904.1	Gene:	Serpinf2 / 18816	MGIID:	107173	Length:	491	Species:	Mus musculus

Alignment Length:	391	Identity:	115/391 - (29%)
Similarity:	194/391 - (49%)	Gaps:	31/391 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 PVHTADVTMADAAHQEFARRLALFSINVYGKLSGQKPGENIVFSPFSIQTCAAMARLGAENETAT 89
            |.|...|..|:.. :..|:.:..|:.:::..::......|:|.||.|:....:...|||:|:|..
Mouse    67 PGHCKSVPTAEET-RRLAQAMMAFTTDLFSLVAQTSTSSNLVLSPLSVALALSHLALGAQNQTLH 130

  Fly    90 QLDQGLGL--ASSDPEQIAHSFHQVLAAYQDSQILRIANKIFVMDGYQLRQEFDQLLSKQFLSAA 152
            .|.:.|.:  .|..|..::| |:|.|.    ...:|:|.:|::..|:.::.:|  |...:.|..|
Mouse   131 SLHRVLHMNTGSCLPHLLSH-FYQNLG----PGTIRLAARIYLQKGFPIKDDF--LEQSERLFGA 188

  Fly   153 QSVDFS-KNVQAAATINNWVEQRTNHLIKDLVPADVLNSESRLVLVNAIHFKGTWQHQFAKHLTR 216
            :.|..: |..:..|.||.||::.|...|:|.:  ..|...:.|:|:|||||.|.|:.:|...||:
Mouse   189 KPVKLTGKQEEDLANINQWVKEATEGKIEDFL--SELPDSTVLLLLNAIHFHGFWRTKFDPSLTQ 251

  Fly   217 PDTFHLDGERTVQVPMM-SLKERFRYADLPALDAMALELPYKDSDLSMLIVLPNTKTGLPALEEK 280
            .|.||||...||.|.|| ::....|:..|...:......|:| :::|.::|:| |.......|..
Mouse   252 KDFFHLDERFTVSVDMMHAVSYPLRWFLLEQPEIQVAHFPFK-NNMSFVVVMP-TYFEWNVSEVL 314

  Fly   281 LRLTTLSQITQSLYETKVALKLPRFKAEFQVELSEVFQKLGMSRMFSDQAEFGKMLQ--SPEPLK 343
            ..||..:....||.|....:.||:...:.|::|.....:||:..:|.     |..|:  |.:.|.
Mouse   315 ANLTWDTLYHPSLQERPTKVWLPKLHLQQQLDLVATLSQLGLQELFQ-----GPDLRGISEQNLV 374

  Fly   344 VSAIIHKAFIEVNEEGTEAAAATGMAVRRKRAIMSPEEPIEFFADHPFTYVLVHQK-DLPLFWGS 407
            ||::.|::.:|::|.|.||||||.:|:.|    ||..   .|..:.||.:.::... .:|||.||
Mouse   375 VSSVQHQSTMELSEAGVEAAAATSVAMNR----MSLS---SFTVNRPFLFFIMEDTIGVPLFVGS 432

  Fly   408 V 408
            |
Mouse   433 V 433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn42Da	NP_524955.2	SERPIN	45..408	CDD:238101	108/369 (29%)
Serpinf2	NP_032904.1	alpha2AP	82..433	CDD:239008	109/373 (29%)
Serpinf2	NP_032904.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	439..491
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010