DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spn42Da and Serpina10

DIOPT Version :9

Sequence 1:	NP_524955.2	Gene:	Spn42Da / 49805	FlyBaseID:	FBgn0265137	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_598301.2	Gene:	Serpina10 / 171154	RGDID:	621220	Length:	436	Species:	Rattus norvegicus

Alignment Length:	379	Identity:	105/379 - (27%)
Similarity:	187/379 - (49%)	Gaps:	16/379 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 AHQEFARRLALFSINVYGKLSGQKPGENIVFSPFSIQTCAAMARLGAENETATQLDQGL---GLA 98
            |.|:.:...:.|..::..|:|.:..| |::||||.:........|||:.||..|::.||   .|:
  Rat    63 ASQQLSNETSSFGFSLLRKISMRHDG-NVIFSPFGLSVAMVNLMLGAKGETKVQVENGLNLQALS 126

  Fly    99 SSDPEQIAHSFHQVLAAYQDSQILRI--ANKIFVMDGYQLRQEFDQLLSKQFLSAAQSVDFSKNV 161
            .:.|..:...|.:|...:..::.|.:  .:..|:...:::::.:..|.:..|.:.....:|..:.
  Rat   127 QAGPLILPALFKRVKETFSSNKKLGLTQGSFAFIHKDFEIKKTYFNLSTMYFDTEYVPTNFRNSS 191

  Fly   162 QAAATINNWVEQRTNHLIKDLVPADVLNSESRLVLVNAIHFKGTWQHQFAKHLTRPDTFHLDGER 226
            ||...:|:::.:.|...|..|.  |.:|.|::|:||:.|.|||.|...|....|..||||||..:
  Rat   192 QARGLMNHYINKETEGKIPKLF--DEINPETKLILVDYILFKGKWLTPFDPIFTEADTFHLDKYK 254

  Fly   227 TVQVPMMSLKERFRYADLPALDAMALELPYKDSDLSMLIVLPNTKTGLPALEEKLRLTTLSQITQ 291
            .|:||||..:..|............|:|||: .:.:||:||........|||:.|....:....|
  Rat   255 AVKVPMMYREGNFASTFDKKFRCHILKLPYQ-GNATMLVVLMEKSGDHLALEDYLTTDLVEMWLQ 318

  Fly   292 SLYETKVALKLPRFKAEFQVELSEVFQKLGMSRMFSDQAEFGKMLQSPEPLKVSAIIHKAFIEVN 356
            .:...|:.:..|:||...:.|:.|:.:::|:.|:||..|:..::......|:||.::.::.:||:
  Rat   319 DMKTRKMEVFFPKFKLNQRYEMHELLKQVGIRRIFSTSADLSELSAVARNLQVSKVVQQSVLEVD 383

  Fly   357 EEGTEAAAATGMAVRRKRAIMSPEEPIEFFADHPFTYVLVHQ-KDLPLFWGSVV 409
            |.|||..:.|   |....|...|  |: ...|.||.:::..: ..:.||.|.||
  Rat   384 ERGTEVVSGT---VSEITAYCMP--PV-IKVDRPFHFIIYEEMSQMLLFLGRVV 431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn42Da	NP_524955.2	SERPIN	45..408	CDD:238101	101/368 (27%)
Serpina10	NP_598301.2	SERPIN	66..430	CDD:294093	101/373 (27%)
Serpina10	NP_598301.2	Heparin-binding. /evidence=ECO:0000250	128..145		3/16 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910