DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn42Da and SERPINA12

DIOPT Version :9

Sequence 1:	NP_524955.2	Gene:	Spn42Da / 49805	FlyBaseID:	FBgn0265137	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_001291390.1	Gene:	SERPINA12 / 145264	HGNCID:	18359	Length:	414	Species:	Homo sapiens

Alignment Length:	434	Identity:	122/434 - (28%)
Similarity:	210/434 - (48%)	Gaps:	65/434 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 PLLGLALF-------------PFPPVHTADVTMADA-----AHQEFARRLALFSINVYGKLSGQK 60
            |.||||:|             .|.|.:...::....     |.:|.||:.......:..||:...
Human     3 PTLGLAIFLAVLLTVKGLLKPSFSPRNYKALSEVQGWKQRMAAKELARQNMDLGFKLLKKLAFYN 67

  Fly    61 PGENIVFSPFSIQTCAAMARLGAENETATQLDQGLGLASSDPEQIAHSFHQVL-AAYQDSQILR- 123
            ||.||..||.||.|..:|..|||::.|..::.||........:.:...||.:: ...|.:|.|:
Human    68 PGRNIFLSPLSISTAFSMLCLGAQDSTLDEIKQGFNFRKMPEKDLHEGFHYIIHELTQKTQDLKL 132

  Fly   124 -IANKIFVMDGYQLRQEF--DQLLSKQFLSAAQSVDFSKNVQ-AAATINNWVEQRT----NHLIK 180
             |.|.:|:....|.:::|  |   :|.|.||...:...:|:: |...||:::.|:|    |:||:
Human   133 SIGNTLFIDQRLQPQRKFLED---AKNFYSAETILTNFQNLEMAQKQINDFISQKTHGKINNLIE 194

  Fly   181 DLVPADVLNSESRLVLVNAIHFKGTWQHQFAKHLTRPDTFHLDGERTVQVPMMSLKERFR----- 240
            ::.|..|      ::|.|.|.|:..|:|:|..::|:.:.|.|:...:|:||||     ||
Human   195 NIDPGTV------MLLANYIFFRARWKHEFDPNVTKEEDFFLEKNSSVKVPMM-----FRSGIYQ 248

  Fly   241 --YADLPALDAMALELPYKDSDLSMLIVLPNTKTGLPALEEKLRLTTLSQITQSLYETKVALKLP 303
              |.|  .|....||:||: .:::.:.:||: :..|..||:.|::.|.|:....|....|.:.:|
Human   249 VGYDD--KLSCTILEIPYQ-KNITAIFILPD-EGKLKHLEKGLQVDTFSRWKTLLSRRVVDVSVP 309

  Fly   304 RFKAEFQVELSEVFQKLGMSRMFSDQAEFGKMLQSP-EPLKVSAIIHKAFIEVNEEGTEAAAATG 367
            |.......:|.:....:|:|::|.:..:..|:  :| ..|||...:|||.::::|.|||.||.||
Human   310 RLHMTGTFDLKKTLSYIGVSKIFEEHGDLTKI--APHRSLKVGEAVHKAELKMDERGTEGAAGTG 372

  Fly   368 MAVRRKRAIMSPEEPIEFFADHPFTYVLVHQKDLP--LFWGSVV 409
            ...      :..|.|:....|.|: .:|::.:.:|  ||.|.:|
Human   373 AQT------LPMETPLVVKIDKPY-LLLIYSEKIPSVLFLGKIV 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn42Da	NP_524955.2	SERPIN	45..408	CDD:238101	109/382 (29%)
SERPINA12	NP_001291390.1	serpinA12_vaspin	40..411	CDD:381026	114/397 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.010