DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn42Da and Serping1

DIOPT Version :9

Sequence 1:	NP_524955.2	Gene:	Spn42Da / 49805	FlyBaseID:	FBgn0265137	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_033906.2	Gene:	Serping1 / 12258	MGIID:	894696	Length:	504	Species:	Mus musculus

Alignment Length:	408	Identity:	114/408 - (27%)
Similarity:	186/408 - (45%)	Gaps:	55/408 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 PFPPVHTADVTMA--DAAHQEFARRLALFSINVYGKLSGQKPGE-NIVFSPFSIQTCAAMARLGA 83
            ||.|...|..:.:  |::..:.:..|..||:.:|...|..|..: |:.||||||.:......|||
Mouse   126 PFCPEPLAQCSDSDRDSSEAKLSEALTDFSVKLYHAFSATKMAKTNMAFSPFSIASLLTQVLLGA 190

  Fly    84 ENETATQLDQGLGLASSDPEQIAHSFHQVLAAYQDSQILRIANKIFVMDGYQLRQEFDQLLSKQF 148
            .:.|.:.|:..|    |.|:..| ..||.|..:....:..::         |:....|..:...:
Mouse   191 GDSTKSNLESIL----SYPKDFA-CVHQALKGFSSKGVTSVS---------QIFHSPDLAIRDTY 241

  Fly   149 LSAAQSV----------DFSKNVQAAATINNWVEQRTNHLIKDLVPADVLNSESRLVLVNAIHFK 203
            ::|:||:          |.:.|::   .||.||.:.|||.|:.|:  |.|.|::.|||:||::..
Mouse   242 VNASQSLYGSSPRVLGPDSAANLE---LINTWVAENTNHKIRKLL--DSLPSDTCLVLLNAVYLS 301

  Fly   204 GTWQHQFAKHLTRPDTFHLDGERTVQVPMM-SLKERFRYADLPALDAMA--LELPYKDSDLSMLI 265
            ..|:..|.........|:.:.  .::|||| |:|......|...|.|..  |:|.:   :||.:|
Mouse   302 AKWKITFEPKKMMAPFFYKNS--MIKVPMMSSVKYPVAQFDDHTLKAKVGQLQLSH---NLSFVI 361

  Fly   266 VLP-NTKTGLPALEEKLRLTTLSQITQSLYETK---VALKLPRFKAEFQVELSEVFQKLGMSRMF 326
            |:| ..|..|..:|:.|..|....|.:.|..:|   ..|.:|..|.:...::..|.:||......
Mouse   362 VVPVFPKHQLKDVEKALNPTVFKAIMKKLELSKFLPTYLTMPHIKVKSSQDMLSVMEKLEFFDFT 426

  Fly   327 SDQAEFGKMLQSPEPLKVSAIIHKAFIEVNEEGTEAAAATGMAVRRKRAIMSPEEPIEFFADHPF 391
            .|....| :.:.|: |:|||:.|:..:|:.|.|.|||||:.::..|...|        |....||
Mouse   427 YDLNLCG-LTEDPD-LQVSAMKHETVLELTESGVEAAAASAISFGRSLPI--------FEVQRPF 481

  Fly   392 TYVLVHQKD-LPLFWGSV 408
            .::|..|:. .|:|.|.|
Mouse   482 LFLLWDQQHRFPVFMGRV 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn42Da	NP_524955.2	SERPIN	45..408	CDD:238101	108/381 (28%)
Serping1	NP_033906.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..67
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	85..141		4/14 (29%)
		serpinG1_C1-INH	141..500	CDD:381006	110/393 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010