DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn42Da and SERPINA3

DIOPT Version :9

Sequence 1:	NP_524955.2	Gene:	Spn42Da / 49805	FlyBaseID:	FBgn0265137	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_001076.2	Gene:	SERPINA3 / 12	HGNCID:	16	Length:	423	Species:	Homo sapiens

Alignment Length:	429	Identity:	127/429 - (29%)
Similarity:	201/429 - (46%)	Gaps:	46/429 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LLPLLGLALF-----------PFPPVHTADVTMAD---AAHQEFARRLALFSINV------YGKL 56
            :||||.|.|.           |..|:...::|..:   ..|.:    |.|.|.||      |.:|
Human     4 MLPLLALGLLAAGFCPAVLCHPNSPLDEENLTQENQDRGTHVD----LGLASANVDFAFSLYKQL 64

  Fly    57 SGQKPGENIVFSPFSIQTCAAMARLGAENETATQLDQGL--GLASSDPEQIAHSFHQVLAAY--- 116
            ..:.|.:|::|||.||.|..|...|||.|.|.|::.:||  .|..:...:|..||..:|...
Human    65 VLKAPDKNVIFSPLSISTALAFLSLGAHNTTLTEILKGLKFNLTETSEAEIHQSFQHLLRTLNQS 129

  Fly   117 QDSQILRIANKIFVMDGYQLRQEFDQLLSKQFLSAAQSVDFSKNVQAAATINNWVEQRTNHLIKD 181
            .|...|.:.|.:||.:...|...|.:...:.:.|.|.:.||..:..|...||::|:..|...|.|
Human   130 SDELQLSMGNAMFVKEQLSLLDRFTEDAKRLYGSEAFATDFQDSAAAKKLINDYVKNGTRGKITD 194

  Fly   182 LVPADVLNSESRLVLVNAIHFKGTWQHQFAKHLTRPDTFHLDGERTVQVPMMSLKERFRYADLP- 245
            |:..  |:|::.:||||.|.||..|:..|....|....|:|..::.|.||||||    .:..:|
Human   195 LIKD--LDSQTMMVLVNYIFFKAKWEMPFDPQDTHQSRFYLSKKKWVMVPMMSL----HHLTIPY 253

  Fly   246 ----ALDAMALELPYKDSDLSMLIVLPNTKTGLPALEEKLRLTTLSQITQSLYETKVA-LKLPRF 305
                .|....:||.| ..:.|.|.:||: :..:..:|..|...||.:...||...::. |.||:|
Human   254 FRDEELSCTVVELKY-TGNASALFILPD-QDKMEEVEAMLLPETLKRWRDSLEFREIGELYLPKF 316

  Fly   306 KAEFQVELSEVFQKLGMSRMFSDQAEFGKMLQSPEPLKVSAIIHKAFIEVNEEGTEAAAATGMAV 370
            .......|:::..:||:...|:.:|:... :.....|.||.::|||.::|.||||||:|||.:.:
Human   317 SISRDYNLNDILLQLGIEEAFTSKADLSG-ITGARNLAVSQVVHKAVLDVFEEGTEASAATAVKI 380

  Fly   371 RRKRAIMSPEEPIEFFADHPFTYVLVHQKDLPLFWGSVV 409
            ....|::.....:.|  :.||..::|......:|:.|.|
Human   381 TLLSALVETRTIVRF--NRPFLMIIVPTDTQNIFFMSKV 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn42Da	NP_524955.2	SERPIN	45..408	CDD:238101	115/379 (30%)
SERPINA3	NP_001076.2	serpinA3_A1AC	40..421	CDD:381019	118/393 (30%)
		RCL	369..394		8/24 (33%)
		O-glycosylated at one site	381..389		1/7 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.010