DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spn42Da and Serpinb7

DIOPT Version :9

Sequence 1:	NP_524955.2	Gene:	Spn42Da / 49805	FlyBaseID:	FBgn0265137	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_569088.1	Gene:	Serpinb7 / 117092	RGDID:	71063	Length:	380	Species:	Rattus norvegicus

Alignment Length:	378	Identity:	114/378 - (30%)
Similarity:	184/378 - (48%)	Gaps:	24/378 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 ALFSINVYGKLSGQKPGENIVFSPFSIQTCAAMARLGAENETATQLDQGL--------GLASSDP 102
            |.|..:::.::...:...|:.||..||.|..::.||||..:.|.|:|:.|        |.:|:..
  Rat     9 AEFGFDLFREMDSSQGNGNVFFSSLSIFTALSLIRLGARGDCARQIDKALHFISPSRQGNSSNSQ 73

  Fly   103 EQIAHSFHQVLA----AYQDSQILRIANKIFVMDGYQLRQEFDQLLSKQFLSAAQSVDFSKNVQA 163
            ..:.:...:|||    :::|.: |.|||.:|....:...:.:.:.....:.:..:.|||:.::|.
  Rat    74 LGLQYQLKRVLADINSSHKDYE-LSIANGVFAEKVFDFHKSYMECAENLYNAKVERVDFTNDIQE 137

  Fly   164 AA-TINNWVEQRTNHLIKDLVPADVLNSESRLVLVNAIHFKGTWQHQFAKHLTRPDTFHLDGERT 227
            .. .||.|:|..|:..||.::....|:|.:.:|||||::|||.|:..|.|..|....|.......
  Rat   138 TRFKINKWIENETHGKIKKVLGDSSLSSSAVMVLVNAVYFKGKWKSAFTKSDTLSCHFRSPSGPG 202

  Fly   228 VQVPMMSLKERFRYADLPALDAMALELPYKDSDLSMLIVLPNTKTGLPALEEKLRLTTLSQITQS 292
            ..|.||..:.||..:.:.......|||.| ...:||.|:||  :..|..:|.||....|...|.|
  Rat   203 KAVNMMHQERRFNLSTIQEPPMQILELQY-HGGISMYIMLP--EDDLSEIESKLSFQNLMDWTNS 264

  Fly   293 --LYETKVALKLPRFKAEFQVELSEVFQKLGMSRMFSDQAEFGKMLQSPEPLKVSAIIHKAFIEV 355
              :....|.:.||:||.|...|:....:.:|:..:|.:.......:.|...|.||.::||:.|||
  Rat   265 RKMKSQYVNVFLPQFKIEKDYEMRSHLKSVGLEDIFVESRADLSGIASGGRLYVSKLMHKSLIEV 329

  Fly   356 NEEGTEAAAATGMAVRRKRAIMSPEEPIEFFADHPFTYVLVHQKDLPLFWGSV 408
            :||||||.|||...:..|   :.||..: |.||.||.:| :.:..:.||.|.|
  Rat   330 SEEGTEATAATESNIVEK---LLPESTV-FRADRPFLFV-IRKNGIILFTGKV 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn42Da	NP_524955.2	SERPIN	45..408	CDD:238101	113/376 (30%)
Serpinb7	NP_569088.1	SERPIN	4..380	CDD:294093	114/378 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm12319
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.930