DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn88Ea and SERPINH1

DIOPT Version :9

Sequence 1:	NP_524954.2	Gene:	Spn88Ea / 49804	FlyBaseID:	FBgn0028984	Length:	427	Species:	Drosophila melanogaster
Sequence 2:	NP_001193943.1	Gene:	SERPINH1 / 871	HGNCID:	1546	Length:	418	Species:	Homo sapiens

Alignment Length:	436	Identity:	95/436 - (21%)
Similarity:	170/436 - (38%)	Gaps:	52/436 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 ILSISLMAVLPAIALAGLCG----VEPDAGLLDQRLNLYKGQQNFAVSMLNVIRQSTPNENVFFS 63
            :|..:|.|.:...|.|...|    :.|.|..|.:|      ....|.|:...:.:....||:..|
Human    12 LLEAALAAEVKKPAAAAAPGTAEKLSPKAATLAER------SAGLAFSLYQAMAKDQAVENILVS 70

  Fly    64 PYSTYHALLLAYFGSSGDTEKELAKVLHLDWADSKEV-------VRSAYILEKMNRKERQSKMPL 121
            |.....:|.|...|....|..:...||..:....:||       :||   |.....:....|:..
Human    71 PVVVASSLGLVSLGGKATTASQAKAVLSAEQLRDEEVHAGLGELLRS---LSNSTARNVTWKLGS 132

  Fly   122 EFSSADRIFFANDLHVTECARNRLAEEVQQIDFKSQTEESRKQINDWIAKQTHDQIRNMLSADEI 186
            .......:.||:|.  ...::.....|..:|:|:.: ..:.:.||:|.|:.|..::..:....|.
Human   133 RLYGPSSVSFADDF--VRSSKQHYNCEHSKINFRDK-RSALQSINEWAAQTTDGKLPEVTKDVER 194

  Fly   187 TPRTRLVLANAAYLKGQWLSQFKTEKTVPMPFYTSPSNYSLVSMMQQKGTFLLNVDEQLRAHVLQ 251
            |....||  ||.:.|..|..:|..:......|..:.|....|.||.:.|.:....||:.:..:::
Human   195 TDGALLV--NAMFFKPHWDEKFHHKMVDNRGFMVTRSYTVGVMMMHRTGLYNYYDDEKEKLQIVE 257

  Fly   252 LPYRTVFESQEKEDSSPDENSDISMVLILPPFNSNSLEDVLSRLNADSLDDSLKQAMPREIEVSL 316
            :|..                ..:|.::||.|.:...||.:...|..:.|...:.:...:.:.:||
Human   258 MPLA----------------HKLSSLIILMPHHVEPLERLEKLLTKEQLKIWMGKMQKKAVAISL 306

  Fly   317 PKFEFEQRLELNPILAKMGVSKMFDESVATFDDLT-SETISIGDSKHVAKIKVDEEGSTAAAATV 380
            ||...|...:|...||.:|:::..|::.|....:: .:.:.:....|....::|.:|:.
Human   307 PKGVVEVTHDLQKHLAGLGLTEAIDKNKADLSRMSGKKDLYLASVFHATAFELDTDGNP------ 365

  Fly   381 LF---TYRSARPVEPAKFECNHPFLFVIYDRTSRSILFTGIYRDPK 423
             |   .|.......|..|..:|||:|::.|..|.|:||.|....||
Human   366 -FDQDIYGREELRSPKLFYADHPFIFLVRDTQSGSLLFIGRLVRPK 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn88Ea	NP_524954.2	SERPIN	39..419	CDD:238101	83/390 (21%)
SERPINH1	NP_001193943.1	serpinH1_CBP1	36..417	CDD:381003	89/412 (22%)
SERPINH1	NP_001193943.1	Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	415..418
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920