DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn88Ea and Serpind1

DIOPT Version :9

Sequence 1:	NP_524954.2	Gene:	Spn88Ea / 49804	FlyBaseID:	FBgn0028984	Length:	427	Species:	Drosophila melanogaster
Sequence 2:	NP_077358.1	Gene:	Serpind1 / 79224	RGDID:	619854	Length:	479	Species:	Rattus norvegicus

Alignment Length:	415	Identity:	115/415 - (27%)
Similarity:	192/415 - (46%)	Gaps:	66/415 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 QRLNLYKGQQNFAVSMLNVIR-QSTPNENVFFSPYSTYHALLLAYFGSSGDTEKELAKVLHL-DW 94
            ||||:...:  ||.::..|:: |:|.::|:|.:|.....|:.:...|..|:|.:|:..|||. |:
  Rat   104 QRLNILNAK--FAFNLYRVLKDQATSSDNIFIAPVGISTAMGMISLGLRGETHEEVHSVLHFKDF 166

  Fly    95 --ADSKEVVRS-----------------AYILEKMNRKERQSKMPL--EFSSADRIFFANDLHVT 138
              |.||..|.:                 .|.|:.:|....|.:.|:  :|.:|.|.|:
  Rat   167 VNASSKYEVTTIHNLFRKLTHRLFRRNFGYTLQSVNDLYIQKQFPIREDFKAAMREFY------- 224

  Fly   139 ECARNRLAEEVQQIDFKSQTEESRKQINDWIAKQTHDQIRNMLSADEITPRTRLVLANAAYLKGQ 203
                   ..|.|:.||......|:  .|..|.|.|...|:..|  :.....|::::.|..|.||.
  Rat   225 -------FAEAQEADFSDPAFISK--ANSHILKLTKGLIKEAL--ENTDSATQMMILNCIYFKGA 278

  Fly   204 WLSQFKTEKTVPMPFYTSPSNYSLVSMMQQKGTFLLNVDEQLRAHVLQLPYRTVFESQEKEDSSP 268
            |:::|..|.|....|..:......|||||.||.||...|::|...:|||.|
  Rat   279 WMNKFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEY-------------- 329

  Fly   269 DENSDISMVLILPPFNSNSLEDVLSRLNADSLDDSLKQAMPREIEVSLPKFEFEQRLELNPILAK 333
              ...|||::::|. ..:.::.:.::|....::...|....|..||.||||:.|:...|..:|..
  Rat   330 --VGGISMLIVIPR-KLSGMKTLEAQLTPQVVERWQKSMTNRTREVLLPKFKLEKNYNLVEVLKS 391

  Fly   334 MGVSKMFDESVATFDDLTSETISIGDSKHVAKIKVDEEGSTAAAATVL-FTYRSARPVEPAKFEC 397
            ||::|:|::: .....::.:.|.|...||.:.|.|:|||:.|||.|.: |...|.:    .:|..
  Rat   392 MGITKLFNKN-GNMSGISDQRIIIDLFKHQSTITVNEEGTQAAAVTTVGFMPLSTQ----VRFTV 451

  Fly   398 NHPFLFVIYDRTSRSILFTGIYRDP 422
            :.||||::|:..:..:||.|...:|
  Rat   452 DRPFLFLVYEHRTSCLLFMGRVANP 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn88Ea	NP_524954.2	SERPIN	39..419	CDD:238101	110/403 (27%)
Serpind1	NP_077358.1	HCII	44..477	CDD:239002	115/415 (28%)
		2 X 11 AA approximate repeats, Asp/Glu-rich (acidic) (hirudin-like)	55..79
		Glycosaminoglycan-binding site. /evidence=ECO:0000250	172..192		2/19 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.020