DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spn88Ea and Serpina5

DIOPT Version :9

Sequence 1:	NP_524954.2	Gene:	Spn88Ea / 49804	FlyBaseID:	FBgn0028984	Length:	427	Species:	Drosophila melanogaster
Sequence 2:	NP_001231668.1	Gene:	Serpina5 / 65051	RGDID:	619817	Length:	442	Species:	Rattus norvegicus

Alignment Length:	384	Identity:	102/384 - (26%)
Similarity:	188/384 - (48%)	Gaps:	34/384 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 QNFAVSMLNVIRQSTPNENVFFSPYSTYHALLLAYFGSSGDTEKELAKVLHLDWADSKE-VVRSA 104
            ::||..:...:....|.:||||||.|...:|.:...||...|:.::.:.|.|.....:| ::...
  Rat    81 RDFAFRLYRALASEAPGQNVFFSPMSVSMSLGMLSLGSGLKTKAQILEGLGLSLQQGQEDMLHKG 145

  Fly   105 YILEKMNRKERQSKMPLEFSSADRIFFANDLHVTE----CARNRLAEEVQQIDFKSQTEESRKQI 165
            :  :::.::..|....|:.|....:|....:|:.:    ..:.....::...:| ...|.::|||
  Rat   146 F--QQLLQQFSQPSDGLQLSLGSALFTDPAVHIRDHFLSAMKTLYMSDMFSTNF-GNPESAKKQI 207

  Fly   166 NDWIAKQTHDQIRNMLSADEITPRTRLVLANAAYLKGQWLSQFKTEKTVPMPFYTSPSNYSLVSM 230
            ||::||:|:.:|.:::.  ::.....:|:.|..:.|.:|.:.|.:..|..|.::.:|.....|.|
  Rat   208 NDYVAKKTNGKIVDLIK--DLDSTHVMVVVNYIFFKAKWQTAFSSTNTHKMDYHVTPKKTIQVPM 270

  Fly   231 MQQKGTFLLNVDEQLRAHVLQLPYRTVFESQEKEDSSPDENSDISMVLILPPFNSNSLEDVLSRL 295
            |.::..:...:|:.:...|:.:||:                .:...:.|||  :...::.|...|
  Rat   271 MNREDIYSYILDQNISCTVVGIPYQ----------------GNTFALFILP--SEGKMKRVEDGL 317

  Fly   296 NADSLDDSLKQAMPREIEVSLPKFEFEQRLELNPILAKMGVSKMFDESVATFDDLTSET-ISIGD 359
            :..:|.:.||....|::::.||||..|...:|..||.|:|:..:| .:.|....||..| |.:.:
  Rat   318 DERTLRNWLKMFTKRQLDLYLPKFSIEGTYKLEKILPKLGIQDIF-TTHADLSGLTDHTNIKLSE 381

  Fly   360 SKHVAKIKVDEEGSTAAAAT-VLFTYRSARPVEPAKFECNHPFLFVIYDRTSRSILFTG 417
            ..|.:.::|||.|:||||:| :|||.||||| ...|.|...|||.||.|.|  ::.|.|
  Rat   382 MVHKSMVEVDESGTTAAASTGILFTLRSARP-SSLKVEFTRPFLVVIMDGT--NLYFIG 437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn88Ea	NP_524954.2	SERPIN	39..419	CDD:238101	102/384 (27%)
Serpina5	NP_001231668.1	alpha-1-antitrypsin_like	81..439	CDD:239011	102/384 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010