DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn88Ea and SERPINB4

DIOPT Version :9

Sequence 1:	NP_524954.2	Gene:	Spn88Ea / 49804	FlyBaseID:	FBgn0028984	Length:	427	Species:	Drosophila melanogaster
Sequence 2:	NP_002965.1	Gene:	SERPINB4 / 6318	HGNCID:	10570	Length:	390	Species:	Homo sapiens

Alignment Length:	406	Identity:	124/406 - (30%)
Similarity:	200/406 - (49%)	Gaps:	36/406 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 NLYKGQQNFAVSMLNVIRQSTPNENVFFSPYSTYHALLLAYFGSSGDTEKELAKVLHLDWADSKE 99
            :|.:....|...:....|:|..| |:|:||.|...||.:...|:..:|.::::||||.|......
Human     3 SLSEANTKFMFDLFQQFRKSKEN-NIFYSPISITSALGMVLLGAKDNTAQQISKVLHFDQVTENT 66

  Fly   100 VVRSA-YILEKMNRKERQ-SKMPLEF---SSADRIFFANDL----------HVTECARNRLAEEV 149
            ..::| |.:::......| .|:..||   :.|..:..||.|          ...:..:......|
Human    67 TEKAATYHVDRSGNVHHQFQKLLTEFNKSTDAYELKIANKLFGEKTYQFLQEYLDAIKKFYQTSV 131

  Fly   150 QQIDFKSQTEESRKQINDWIAKQTHDQIRNMLSADEITPRTRLVLANAAYLKGQWLSQFKTEKTV 214
            :..||.:..|||||:||.|:..||:::|:|:.....|...|.|||.||.|.||||.::||.|.|.
Human   132 ESTDFANAPEESRKKINSWVESQTNEKIKNLFPDGTIGNDTTLVLVNAIYFKGQWENKFKKENTK 196

  Fly   215 PMPFYTSPSNYSLVSMMQQKGTFLLNVDEQLRAHVLQLPYRTVFESQEKEDSSPDENSDISMVLI 279
            ...|:.:.:.|..|.||:|..:|...:.|.::|.||::||:               ..|:||:::
Human   197 EEKFWPNKNTYKSVQMMRQYNSFNFALLEDVQAKVLEIPYK---------------GKDLSMIVL 246

  Fly   280 LPPFNSNSLEDVLSRLNADSLDD--SLKQAMPREIEVSLPKFEFEQRLELNPILAKMGVSKMFDE 342
            ||. ..:.|:.:..:|.|:.|.:  ||:......:::.||:|:.|:..:|...|..||:..:|:.
Human   247 LPN-EIDGLQKLEEKLTAEKLMEWTSLQNMRETCVDLHLPRFKMEESYDLKDTLRTMGMVNIFNG 310

  Fly   343 SVATFDDLT-SETISIGDSKHVAKIKVDEEGSTAAAATVLFTYRSARPVEPAKFECNHPFLFVIY 406
            . |....:| |..:|:....|.|.::|.|||..|||||.:.....:.|....:|.|||||||.|.
Human   311 D-ADLSGMTWSHGLSVSKVLHKAFVEVTEEGVEAAAATAVVVVELSSPSTNEEFCCNHPFLFFIR 374

  Fly   407 DRTSRSILFTGIYRDP 422
            ...:.||||.|.:..|
Human   375 QNKTNSILFYGRFSSP 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn88Ea	NP_524954.2	SERPIN	39..419	CDD:238101	122/397 (31%)
SERPINB4	NP_002965.1	SERPIN	4..390	CDD:320777	123/403 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920