DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spn88Ea and serpinf2a

DIOPT Version :9

Sequence 1:	NP_524954.2	Gene:	Spn88Ea / 49804	FlyBaseID:	FBgn0028984	Length:	427	Species:	Drosophila melanogaster
Sequence 2:	XP_688797.1	Gene:	serpinf2a / 560308	ZFINID:	ZDB-GENE-060822-1	Length:	457	Species:	Danio rerio

Alignment Length:	441	Identity:	108/441 - (24%)
Similarity:	190/441 - (43%)	Gaps:	81/441 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LMAVLPAIALAGLCGVEPDAGLLDQRLNLYKGQQN----------FAVSMLNVIRQSTPNENVFF 62
            |:.:||.....||. ...:.|...::.|...|.::          ..:::|..::..:...|:..
Zfish     6 LVLILPFSFNFGLL-ASNETGDAKEKCNDVLGLESQRAVGAAVAKLGLTLLEKLQPGSEQPNIII 69

  Fly    63 SPYSTYHALLLAYFGSSGDTEKELAKVLHLDWADSKEVVRSAYILEKMNRKERQSKMPLEFSSAD 127
            ||.|...||.....|:..:||::|.:|||     :||:......|..:.          |..:|.
Zfish    70 SPLSVSLALAELALGARNNTEEKLLEVLH-----AKELPHFHETLSCLQ----------EHLTAK 119

  Fly   128 RIFFANDLHV----------TECARNRLAEEVQQIDFKSQTEESRKQINDWIAKQTHDQIRNMLS 182
            .:..|:.|::          .:.|.|....|..|:       .|.:.:|.|:.:.|:.||.|.:|
Zfish   120 AVKMASRLYLVPGYTVNPDFVDRALNLYKSESAQL-------TSIEDVNRWVEETTNGQITNFMS 177

  Fly   183 ADEITPRTRLVLANAAYLKGQWLSQFKTEKTVPMPFYTSPSNYSLVSMMQ-QKGTFLLNVDEQLR 246
            :  :.|...|:|.||.:.||:|.|:|.::.|....|:........|.||. .:....:.||....
Zfish   178 S--LPPNVVLMLINAIHFKGEWQSRFNSKYTKENIFHIDRKTSVKVDMMMGSQYPLSMFVDRTDG 240

  Fly   247 AHVLQLPYRTVFESQEKEDSSPDENSDISMVLILPPFNSNSLEDVLSRLNADSLDDSLKQAMPRE 311
            ..|.:||:|                .::|:::|:|.....:|.:|.::||.    ..:....|||
Zfish   241 TQVARLPFR----------------GNMSLLVIMPRLQHENLSNVAAKLNI----SDMYARFPRE 285

  Fly   312 --IEVSLPKFEFEQRLELNPILAKMGVSKMFDESVATFDDLT---SETISIGDSKHVAKIKVDEE 371
              :.|:||||:.|.:.:|...|..||:..:|     |..||:   ...:.:...:|.:.:::.||
Zfish   286 RSMHVTLPKFKLEYKQDLRQALTSMGLGFLF-----TGPDLSRIAPGPLVVSGVQHASNMELSEE 345

  Fly   372 GSTAAAATVLFTYRSARPVEPAKFECNHPFLFVIYDRTSRSILFTGIYRDP 422
            |:.|:|||.....|:.     :.|..|.||:|.:.|.||.:.||.||..:|
Zfish   346 GAEASAATSFTLVRTI-----SFFSVNMPFIFALVDDTSYTPLFLGIVTNP 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn88Ea	NP_524954.2	SERPIN	39..419	CDD:238101	99/405 (24%)
serpinf2a	XP_688797.1	SERPIN	54..388	CDD:294093	98/387 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.010