DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn88Ea and SERPINI1

DIOPT Version :9

Sequence 1:	NP_524954.2	Gene:	Spn88Ea / 49804	FlyBaseID:	FBgn0028984	Length:	427	Species:	Drosophila melanogaster
Sequence 2:	NP_001116224.1	Gene:	SERPINI1 / 5274	HGNCID:	8943	Length:	410	Species:	Homo sapiens

Alignment Length:	444	Identity:	120/444 - (27%)
Similarity:	205/444 - (46%)	Gaps:	63/444 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MHILSISLMAVLPAIALAGLCGVEPDAGLLDQRLNLYKGQQNFAVSMLNVIRQSTPNENVFFSPY 65
            |..|.:..:.||.::|..   ...|:..:.|..:|:|           |.:|.:..:||:.|||.
Human     1 MAFLGLFSLLVLQSMATG---ATFPEEAIADLSVNMY-----------NRLRATGEDENILFSPL 51

  Fly    66 STYHALLLAYFGSSGDTEKELAKVLHLDWADSKEVVRSAYILEKMN---RKERQSKMPLEFSSAD 127
            |...|:.:...|:.|.|:||:...:..|...:.|  ..:::.|..|   .||.|..|.:    |:
Human    52 SIALAMGMMELGAQGSTQKEIRHSMGYDSLKNGE--EFSFLKEFSNMVTAKESQYVMKI----AN 110

  Fly   128 RIFFANDLHVTE----CARNRLAEEVQQIDFKSQTEESRKQINDWIAKQTHDQIRNMLSADEITP 188
            .:|..|..||.|    ..:......|..:|| ||.......||.|:...|::.:::::|..:...
Human   111 SLFVQNGFHVNEEFLQMMKKYFNAAVNHVDF-SQNVAVANYINKWVENNTNNLVKDLVSPRDFDA 174

  Fly   189 RTRLVLANAAYLKGQWLSQFKTEKTVPMPFYTSPSNYSLVSMMQQKGTFLLN--VDEQLRA---- 247
            .|.|.|.||.|.||.|.|||:.|.|....|.....:...:.||.|:|.|...  .|....|
Human   175 ATYLALINAVYFKGNWKSQFRPENTRTFSFTKDDESEVQIPMMYQQGEFYYGEFSDGSNEAGGIY 239

  Fly   248 HVLQLPYRTVFESQEKEDSSPDENSDISMVLILP----PFNSNSLEDVLSRLNADSLDDSLKQAM 308
            .||::||               |..:|||:|:|.    |.  .:||.::.....:...:|:|:
Human   240 QVLEIPY---------------EGDEISMMLVLSRQEVPL--ATLEPLVKAQLVEEWANSVKK-- 285

  Fly   309 PREIEVSLPKFEFEQRLELNPILAKMGVSKMF--DESVATFDDLTSETISIGDSKHVAKIKVDEE 371
             :::||.||:|..||.::|..:|..:|::::|  |.::....|  ::.|.:..:.|.:.::|:||
Human   286 -QKVEVYLPRFTVEQEIDLKDVLKALGITEIFIKDANLTGLSD--NKEIFLSKAIHKSFLEVNEE 347

  Fly   372 GSTAAAATVLFTYRSARPVEPAKFECNHPFLFVIYDRTSRSILFTGIYRDPKTI 425
            ||.|||.:.:........:.| :...:|||.|:|.:|.:.:|||.|....|:|:
Human   348 GSEAAAVSGMIAISRMAVLYP-QVIVDHPFFFLIRNRRTGTILFMGRVMHPETM 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn88Ea	NP_524954.2	SERPIN	39..419	CDD:238101	109/398 (27%)
SERPINI1	NP_001116224.1	neuroserpin	23..410	CDD:239003	114/419 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BBFJ
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920