DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn88Ea and SERPINB8

DIOPT Version :9

Sequence 1:	NP_524954.2	Gene:	Spn88Ea / 49804	FlyBaseID:	FBgn0028984	Length:	427	Species:	Drosophila melanogaster
Sequence 2:	NP_001353127.1	Gene:	SERPINB8 / 5271	HGNCID:	8952	Length:	374	Species:	Homo sapiens

Alignment Length:	404	Identity:	120/404 - (29%)
Similarity:	203/404 - (50%)	Gaps:	48/404 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 NLYKGQQNFAVSMLNVIRQSTPNENVFFSPYSTYHALLLAYFGSSGDTEKELAKVLHLDWADSKE 99
            :|.:....||:|:..::.:...:.||||||.|...||.:.:.|:.|.|..::::.|.| :.|. :
Human     3 DLCEANGTFAISLFKILGEEDNSRNVFFSPMSISSALAMVFMGAKGSTAAQMSQALCL-YKDG-D 65

  Fly   100 VVRS-AYILEKMNRKERQSKMPLEFSSADRIF------FANDLHVTECARNRLAEEVQQIDFKSQ 157
            :.|. ..:|.::||...|..:    .:|:|:|      |..|.  .|..:.....|::::.|...
Human    66 IHRGFQSLLSEVNRTGTQYLL----RTANRLFGEKTCDFLPDF--KEYCQKFYQAELEELSFAED 124

  Fly   158 TEESRKQINDWIAKQTHDQIRNMLSADEITPRTRLVLANAAYLKGQWLSQFKTEKTVPMPFYTSP 222
            |||.||.||||:|::|..:|..:|.|..:.|.|:|||.||.|.||:|..||..:.|..|.|.|:.
Human   125 TEECRKHINDWVAEKTEGKISEVLDAGTVDPLTKLVLVNAIYFKGKWNEQFDRKYTRGMLFKTNE 189

  Fly   223 SNYSLVSMMQQKGTFLLNVDEQLRAHVLQLPYRTVFESQEKEDSSPDENSDISMVLILPPFNSN- 286
            .. ..|.||.::..|.:...:::...||:|||               ...::|||::||..|::
Human   190 EK-KTVQMMFKEAKFKMGYADEVHTQVLELPY---------------VEEELSMVILLPDDNTDL 238

  Fly   287 -------SLEDVLSRLNADSLDDSLKQAMPREIEVSLPKFEFEQRLELNPILAKMGVSKMFDESV 344
                   :.|...:..|::.|..|       :::|.||:.:.|:..:|.|.|.::|:...|||:.
Human   239 AVVEKALTYEKFKAWTNSEKLTKS-------KVQVFLPRLKLEESYDLEPFLRRLGMIDAFDEAK 296

  Fly   345 ATFDDLTSE-TISIGDSKHVAKIKVDEEGSTAAAATVLFTYRSARPVEPAKFECNHPFLFVIYDR 408
            |.|..:::| .:.:....|...::|:|||:.|||||.:........:|| :|..:|||||.|...
Human   297 ADFSGMSTEKNVPLSKVAHKCFVEVNEEGTEAAAATAVVRNSRCSRMEP-RFCADHPFLFFIRHH 360

  Fly   409 TSRSILFTGIYRDP 422
            .:..|||.|.:..|
Human   361 KTNCILFCGRFSSP 374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn88Ea	NP_524954.2	SERPIN	39..419	CDD:238101	118/395 (30%)
SERPINB8	NP_001353127.1	SERPIN	4..374	CDD:320777	119/401 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920