Protein Alignment Spn88Ea and SERPINA5

DIOPT Version :10

• Sequence 1: NP_524954.2
• Gene: Spn88Ea / 49804
• FlyBaseID: FBgn0028984
• Length: 427
• Species: Drosophila melanogaster
• Sequence 2: NP_000615.3
• Gene: SERPINA5 / 5104
• HGNCID: 8723
• Length: 406
• Species: Homo sapiens
• Alignment Length: 394
• Identity: 103/394 - (26%)
• Similarity: 187/394 - (47%)
• Gaps: 43/394 - (10%)

  Fly    40 QQNFAVSMLNVIRQSTPNENVFFSPYSTYHALLLAYFGSSGDTEKELAK--VLHLDWADSKEVVR 102
            :::|...:...:..:.|::::||||.|...:|.:...|:...|:.::.:  .|:|..:..||:.|
Human    45 RRDFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNLQKSSEKELHR 109

  Fly   103 S-AYILEKMNRKERQSKMPLEFSSA---DRIFFANDLHVTECARNRLAEEVQQIDFKSQTEES-- 161
            . ..:|:::|  :.:....|...:|   |.:....|..|:......||:     .|.:...:|
Human   110 GFQQLLQELN--QPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLAD-----TFPTNFRDSAG 167

  Fly   162 -RKQINDWIAKQTHDQIRNMLSADEITPRTRLVLANAAYLKGQWLSQFKTEKTVPMPFYTSPSNY 225
             .|||||::||||..:|.::|.  .:.....:::.|..:.|.:|.:.|..:.|....||.:....
Human   168 AMKQINDYVAKQTKGKIVDLLK--NLDSNAVVIMVNYIFFKAKWETSFNHKGTQEQDFYVTSETV 230

  Fly   226 SLVSMMQQKGTFLLNVDEQLRAHVLQLPYRTVFESQEKEDSSPDENSDISMVLILPPFNSNSLED 290
            ..|.||.::..:...:|..|...|:.:||:                .:.:.:.|||  :...::.
Human   231 VRVPMMSREDQYHYLLDRNLSCRVVGVPYQ----------------GNATALFILP--SEGKMQQ 277

  Fly   291 VLSRLNADSLDDSLKQAMPREIEVSLPKFEFEQRLELNPILAKMGVSKMFDESVATFDDLTSET- 354
            |.:.|:..:|...||....|::|:.||||..|...:|..:|..:|:|.:| .|.|....:::.:
Human   278 VENGLSEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVF-TSHADLSGISNHSN 341

  Fly   355 ISIGDSKHVAKIKVDEEGSTAAAAT-VLFTYRSARPVEPAKFECNHPFLFVIYDRTSRSILFTGI 418
            |.:.:..|.|.::|||.|:.||||| .:||:|||| :...:...|.|||..|.|   .:|||.|.
Human   342 IQVSEMVHKAVVEVDESGTRAAAATGTIFTFRSAR-LNSQRLVFNRPFLMFIVD---NNILFLGK 402

  Fly   419 YRDP 422
            ...|
Human   403 VNRP 406

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spn88Ea	NP_524954.2	serpin_crustaceans_chelicerates_insects	36..422	CDD:381059	102/392 (26%)
SERPINA5	NP_000615.3	serpinA5_PCI	44..406	CDD:381021	102/392 (26%)