DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn88Ea and CG43366

DIOPT Version :9

Sequence 1:	NP_524954.2	Gene:	Spn88Ea / 49804	FlyBaseID:	FBgn0028984	Length:	427	Species:	Drosophila melanogaster
Sequence 2:	NP_610188.2	Gene:	CG43366 / 35519	FlyBaseID:	FBgn0263109	Length:	2140	Species:	Drosophila melanogaster

Alignment Length:	530	Identity:	98/530 - (18%)
Similarity:	185/530 - (34%)	Gaps:	137/530 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MHILSISLMAVLPAIAL----AGLCGVEPDAGLLDQRLNLYKGQQN-FAVSMLNVI--RQSTPNE 58
            :::::.|..:..|.:.|    ....|:|....::|:.|..:....| .|.|....|  .:.:...
  Fly  1642 INLMASSTQSTRPPVKLDPSPESSQGLEASTAMMDEDLQSFARLCNELAFSYWRAITSEKISSAR 1706

  Fly    59 NVFFSPYSTYHALLLAYFGSSGDTEKELAKVLHLD-------------------WADSKEVVRSA 104
            ::..||::....|.:.:.|:.|.|..|:.::|.||                   .|...::..:|
  Fly  1707 SLVISPFALTSMLSMVFLGARGSTSGEMNEILKLDDMVTFNPHLIFKNITNSVEQASDSDIATAA 1771

  Fly   105 YILEKMNRKERQSKMPLEFSSADRIFFANDLHVTECARNRLAEEVQQIDFKSQTEESRKQINDWI 169
            ::.|..:.:.....:|         ||      .|..:...|..|::::|....:..|::.|..:
  Fly  1772 FVREIFSDRANGKILP---------FF------KEKTQQLYAGHVEEVNFHVVNDIVRRRTNLLV 1821

  Fly   170 AKQTHDQIRNMLSADEITPRTRLVLANAAYLKGQWLSQFKTEKTVPMPFYTSPS--NYSLV---S 229
            .:.|..::...|..:.:.....|...:|...:........|::...|.|...|:  ...||   :
  Fly  1822 KRHTMGKVLEYLRTNSVWVNGPLATISANLFQTDCSHGSTTDRDGEMFFQVHPTVRQRRLVPIPA 1886

  Fly   230 MMQQKGTFLLNVDEQLRAHVLQLPYRTVFESQEKEDSSPDENSDISMVLILPPFNSN-SLEDVLS 293
            ::.:.| ||...:..|.|.|:               |.....:.:|.|.::|...|: |..|.|.
  Fly  1887 VLYRSG-FLAGYEPSLDATVV---------------SFGRVQNTVSTVYVMPGHQSSISPMDNLD 1935

  Fly   294 RLNADSLDDSL--KQAMPR---------EIEVSLPKFEFEQRLELNPILAKMGVSKMFDESVATF 347
            ||....::.:.  |||..|         .:||.||:|.....:..:..|.|||:..:|....|..
  Fly  1936 RLERSLVETAFSDKQAWRRLLTSLMDRPGMEVQLPRFSHRSFVNASLGLQKMGLRGLFKSDFADL 2000

  Fly   348 DDLT---------SETISI------GDSK-----HVAKI-------------KVDEEGSTAAAAT 379
            ..||         |:.|.|      |:.|     ||...             ..|::...::...
  Fly  2001 RGLTGAGNRDIFLSDMIQINTFSTCGEEKISEHHHVEMYPAPPLRKRNKDVDATDDDAFDSSERV 2065

  Fly   380 VLF--------------------TY---------RSARPVEPAKFECNHPFLFVIYDRTSRSILF 415
            |.|                    .|         |.||..:..:...:.|||:.:....:..|||
  Fly  2066 VDFGSLVQESALGRGFYDDLLDPKYLELPLPLRPRQARVPDAPRLRFDKPFLYFVRHNPTGMILF 2130

  Fly   416 TGIYRDPKTI 425
            .|.: :|:.:
  Fly  2131 MGRF-NPRLL 2139

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn88Ea	NP_524954.2	SERPIN	39..419	CDD:238101	90/480 (19%)
CG43366	NP_610188.2	SERPIN	1687..2136	CDD:294093	90/480 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11461
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100