DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn88Ea and LOC299282

DIOPT Version :9

Sequence 1:	NP_524954.2	Gene:	Spn88Ea / 49804	FlyBaseID:	FBgn0028984	Length:	427	Species:	Drosophila melanogaster
Sequence 2:	NP_001376144.2	Gene:	LOC299282 / 299282	RGDID:	3745	Length:	413	Species:	Rattus norvegicus

Alignment Length:	436	Identity:	118/436 - (27%)
Similarity:	195/436 - (44%)	Gaps:	45/436 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LSISLMAVLPAIALAGLCGVE----PDAGLLDQ--RLNLYKGQQNFAVSMLNVIRQSTPNENVFF 62
            |.:.:..:.||:...|..|.:    .|.|...|  .|.|.....:||:|:...:....|::||.|
  Rat     7 LGLLMAGICPAVLCDGTLGRDTLSHEDHGKGRQLHSLTLASSNTDFALSLYKKLALRNPDKNVVF 71

  Fly    63 SPYSTYHALLLAYFGSSGDTEKELAKVLHLDWAD-SKEVVRSAY--ILEKMNRKERQSKMPLEFS 124
            ||.|...||.:...|:...|.:|:.:.|..:..: ::|.:...:  :|:::::.|.|    :|.:
  Rat    72 SPLSISAALTILSLGAKDSTMEEILEGLKFNLTEITEEEIHQGFGHLLQRLSQPEDQ----VEIN 132

  Fly   125 SADRIFFANDLHV----TECARNRLAEEVQQIDFKSQTEESRKQINDWIAKQTHDQIRNMLSADE 185
            :...:|...:..:    .|..|.....|....||| |..|::|.|||:::.||..:|..:.|  :
  Rat   133 TGSALFIDKEQPILSEFQEKTRALYQAEAFIADFK-QPNEAKKLINDYVSNQTQGKIAELFS--D 194

  Fly   186 ITPRTRLVLANAAYLKGQWLSQFKTEKTVPMPFYTSPSNYSLVSMMQQKGTFLLNV-DEQLRAHV 249
            :..||.:||.|....||:|...|....|....||........|.||:.|......| ||:|...|
  Rat   195 LEERTSMVLVNYLLFKGKWKVPFNPNDTFESEFYLDEKRSVKVPMMKIKEVTTPYVRDEELSCSV 259

  Fly   250 LQLPYRTVFESQEKEDSSPDENSDISMVLILPPFNSNSLEDVLSRLNADSLDDSLKQAMPREI-E 313
            |:|.|                ..:.|.:.|||  :...::.|.|.|..::|.......:||.| :
  Rat   260 LELKY----------------TGNASALFILP--DQGKMQQVESSLQPETLKKWKDSLIPRIIND 306

  Fly   314 VSLPKFEFEQRLELNPILAKMGVSKMFDESVATFDDLT-SETISIGDSKHVAKIKVDEEGSTAAA 377
            :.:|||.......|..:|.::|:.|:|.:. |....:| ::.:.:....|.|.:.|||.|:.|.|
  Rat   307 LRMPKFSISTDYSLKEVLPELGIKKVFSQQ-ADLSRITGTKDLYVSQVVHKAVLDVDETGTEATA 370

  Fly   378 ATVLFTYRSARPVEPAKFECNHPFLFVIYDRTSRSILFTGIYRDPK 423
            ||.:.|....   :|.....|.||:.||.|..|:||||.....:||
  Rat   371 ATGVATVIRR---QPRTLNFNRPFMVVITDMDSQSILFVAKITNPK 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn88Ea	NP_524954.2	SERPIN	39..419	CDD:238101	106/389 (27%)
LOC299282	NP_001376144.2	serpinA3_A1AC	36..413	CDD:381019	109/405 (27%)
LOC299282	NP_001376144.2	RCL	365..389		7/26 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010