DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn88Ea and Serpina6

DIOPT Version :9

Sequence 1:	NP_524954.2	Gene:	Spn88Ea / 49804	FlyBaseID:	FBgn0028984	Length:	427	Species:	Drosophila melanogaster
Sequence 2:	NP_001009663.1	Gene:	Serpina6 / 299270	RGDID:	1595901	Length:	396	Species:	Rattus norvegicus

Alignment Length:	435	Identity:	96/435 - (22%)
Similarity:	181/435 - (41%)	Gaps:	72/435 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LSISLMAVLPAIALAGLCGVEPDAGLLDQRLNLYKG----QQNFAVSMLNVIRQSTPNENVFFSP 64
            :|::|...|..:..:||...:...   ::..|.::|    ..:||.::...:....|::|...||
  Rat     1 MSLALYTCLLWLCTSGLWTAQAST---NESSNSHRGLAPTNVDFAFNLYQRLVALNPDKNTLISP 62

  Fly    65 YSTYHALLLAYFGSSGDTEKELAKVLHLDWADSKEVVRSAYILEKMNRKERQSKMPLEFSSADRI 129
            .|...||.:...||: .|:...:...:|......|:.:|   .:.:|...:||...||.:..:.:
  Rat    63 VSISMALAMVSLGSA-QTQSLQSLGFNLTETSEAEIHQS---FQYLNYLLKQSDTGLEMNMGNAM 123

  Fly   130 FFANDLHVTEC----ARNRLAEEVQQIDFKSQTEESRKQINDWIAKQTHDQIRNMLSADEITPRT 190
            |....|.:.:.    .:.....|...|||:..|:.| :|||..:..:|..:|.::.|  ::....
  Rat   124 FLLQKLKLKDSFLADVKQYYESEALAIDFEDWTKAS-QQINQHVKDKTQGKIEHVFS--DLDSPA 185

  Fly   191 RLVLANAAYLKGQWLSQFKTEKTVPMPFYTSPSNYSLVSMMQQKGTFLLNVDEQLRAHVLQLPY- 254
            ..:|.|..:|:|.|...|..|.|....||.:.::...|.||.|.|:.....|......::|:.|
  Rat   186 SFILVNYIFLRGIWELPFSPENTREEDFYVNETSTVKVPMMVQSGSIGYFRDSVFPCQLIQMDYV 250

  Fly   255 --RTVFESQEKEDSSPDENSDISMVLILPPFNSNSLEDVLSRLNADSLDDSLKQAMPREIEVSLP 317
              .|.|                   .|||  :...::.|::.|:.|::|...|...||::.:.:|
  Rat   251 GNGTAF-------------------FILP--DQGQMDTVIAALSRDTIDRWGKLMTPRQVNLYIP 294

  Fly   318 KFEFEQRLELNPILAKMGVSKMFDESVATFDDLTSETISIGDSK---------HVAKIKVDEEGS 373
            ||......:|..:|..:.:.          |.||:::...|::|         |.|.:::||
  Rat   295 KFSISDTYDLKDMLEDLNIK----------DLLTNQSDFSGNTKDVPLTLTMVHKAMLQLDE--- 346

  Fly   374 TAAAATVLFTYRSARPV----EPAKFECNHPFLFVIYDRTSRSIL 414
                ..||....:..|:    ||...:.|.||:.:::|:.:.|.|
  Rat   347 ----GNVLPNSTNGAPLHLRSEPLDIKFNKPFILLLFDKFTWSSL 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn88Ea	NP_524954.2	SERPIN	39..419	CDD:238101	90/400 (23%)
Serpina6	NP_001009663.1	alpha-1-antitrypsin_like	37..392	CDD:239011	89/396 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.110