DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn88Ea and Serpinh1

DIOPT Version :9

Sequence 1:	NP_524954.2	Gene:	Spn88Ea / 49804	FlyBaseID:	FBgn0028984	Length:	427	Species:	Drosophila melanogaster
Sequence 2:	NP_058869.2	Gene:	Serpinh1 / 29345	RGDID:	69302	Length:	417	Species:	Rattus norvegicus

Alignment Length:	441	Identity:	97/441 - (21%)
Similarity:	175/441 - (39%)	Gaps:	50/441 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MHILSISLMAVLPAIALAGLC--GVEPDAGLLDQRLN-----LYKGQQNFAVSMLNVIRQSTPNE 58
            |..|.:..:.:| |:|||...  .||..|....::|:     |.:.....|.|:...:.:....|
  Rat     1 MRSLLLGTLCLL-AVALAAEVKKPVEATAPGTAEKLSSKATTLAERSTGLAFSLYQAMAKDQAVE 64

  Fly    59 NVFFSPYSTYHALLLAYFGSSGDTEKELAKVLHLDWADSKEV-------VRSAYILEKMNRKERQ 116
            |:..||.....:|.|...|....|..:...||..:....:||       :||   |.....:...
  Rat    65 NILLSPLVVASSLGLVSLGGKATTASQAKAVLSAEKLRDEEVHTGLGELLRS---LSNSTARNVT 126

  Fly   117 SKMPLEFSSADRIFFANDLHVTECARNRLAEEVQQIDFKSQTEESRKQINDWIAKQTHDQIRNML 181
            .|:.........:.||:|.  ...::.....|..:|:|:.: ..:.:.||:|.::.|..::..:.
  Rat   127 WKLGSRLYGPSSVSFADDF--VRSSKQHYNCEHSKINFRDK-RSALQSINEWASQTTDGKLPEVT 188

  Fly   182 SADEITPRTRLVLANAAYLKGQWLSQFKTEKTVPMPFYTSPSNYSLVSMMQQKGTFLLNVDEQLR 246
            ...|.|....||  ||.:.|..|..:|..:......|..:.|....|:||.:.|.:....||:.:
  Rat   189 KDVERTDGALLV--NAMFFKPHWDEKFHHKMVDNRGFMVTRSYTVGVTMMHRTGLYNYYDDEKEK 251

  Fly   247 AHVLQLPYRTVFESQEKEDSSPDENSDISMVLILPPFNSNSLEDVLSRLNADSLDDSLKQAMPRE 311
            ..::::|..                ..:|.::||.|.:...||.:...|..:.|...:.:...:.
  Rat   252 LQLVEMPLA----------------HKLSSLIILMPHHVEPLERLEKLLTKEQLKTWMGKMQKKA 300

  Fly   312 IEVSLPKFEFEQRLELNPILAKMGVSKMFDESVATFDDLT-SETISIGDSKHVAKIKVDEEGSTA 375
            :.:||||...|...:|...||.:|:::..|::.|....:: .:.:.:....|....:.|.||:.
  Rat   301 VAISLPKGVVEVTHDLQKHLAGLGLTEAIDKNKADLSRMSGKKDLYLASVFHATAFEWDTEGNP- 364

  Fly   376 AAATVLF---TYRSARPVEPAKFECNHPFLFVIYDRTSRSILFTGIYRDPK 423
                  |   .|.......|..|..:|||:|::.|..|.|:||.|....||
  Rat   365 ------FDQDIYGREELRSPKLFYADHPFIFLVRDNQSGSLLFIGRLVRPK 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn88Ea	NP_524954.2	SERPIN	39..419	CDD:238101	83/390 (21%)
Serpinh1	NP_058869.2	serpinH1_CBP1	35..416	CDD:381003	87/406 (21%)
Serpinh1	NP_058869.2	Prevents secretion from ER. /evidence=ECO:0000305	414..417
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010