DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn88Ea and Serpinf1

DIOPT Version :9

Sequence 1:	NP_524954.2	Gene:	Spn88Ea / 49804	FlyBaseID:	FBgn0028984	Length:	427	Species:	Drosophila melanogaster
Sequence 2:	NP_808788.1	Gene:	Serpinf1 / 287526	RGDID:	631369	Length:	418	Species:	Rattus norvegicus

Alignment Length:	426	Identity:	96/426 - (22%)
Similarity:	168/426 - (39%)	Gaps:	52/426 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 PAIALAGLCGVEPDAGLLDQRLN-LYKGQQNFAVSMLNVIRQSTPNENVFFSPYSTYHALLLAYF 76
            ||....|...||.|.......:| |.....||...:..:...:....|:..||.|...||.....
  Rat    30 PAPDSTGEPVVEEDDPFFKAPVNKLAAAVSNFGYDLYRLRSGAVSTGNILLSPLSVATALSALSL 94

  Fly    77 GSSGDTEKELAKVLHLDWADSKEVVRSAY--ILEKMNRKERQSKMPLEFSSADRIFFANDLHVTE 139
            |:...||..:.:.|:.|..::.: :.|.|  :|..:...|:      .|.||.||.|...|.|..
  Rat    95 GAEQRTESVIHRALYYDLINNPD-IHSTYKELLASVTAPEK------NFKSASRIVFERKLRVKS 152

  Fly   140 C----------ARNRLAEEVQQIDFKSQTEESRKQINDWIAKQTHDQIRNMLSADEITPRTRLVL 194
            .          .|.|:.....:||.        ::||:|:..|...:|..  |..|:.....::|
  Rat   153 SFVAPLEKSYGTRPRILTGNPRIDL--------QEINNWVQAQMKGKIAR--STREMPSALSILL 207

  Fly   195 ANAAYLKGQWLSQFKTEKTVPMPFYTSPSNYSLVSMMQQ-KGTFLLNVDEQLRAHVLQLPYRTVF 258
            ...||.||||.::|.:.||....|:........|.||.. |......:|..|...:.|||.
  Rat   208 LGVAYFKGQWATKFDSRKTTLQDFHLDEDRTVRVPMMSDPKAILRYGLDSDLNCKIAQLPL---- 268

  Fly   259 ESQEKEDSSPDENSDISMVLILPPFNSNSLEDVLSRLNADSLDDSLKQAMPREIEVSLPKFEFEQ 323
                        ...:|::..||...:.:|..:...|.::.:.|..::....:..:::||.:...
  Rat   269 ------------TGSMSIIFFLPLTVTQNLTMIEESLTSEFVHDIDRELKTIQAVLTVPKLKLSY 321

  Fly   324 RLELNPILAKMGVSKMFDESVATFDDLTSETISIGDSKHVAKIKVDEEGSTAAAATVLFTYRSAR 388
            ..::...|..|.:..:|:.  ..|..:|.:.:.:...:|.|..:.:|||:..::...|...|...
  Rat   322 EGDVTNSLQDMKLQSLFES--PDFSKITGKPVKLTQVEHRAAFEWNEEGAGTSSNPDLQPVRLTF 384

  Fly   389 PVEPAKFECNHPFLFVIYDRTSRSILFTGIYRDPKT 424
            |::   :..|.||:||:.|..:.::||.|...||.:
  Rat   385 PLD---YHLNRPFIFVLRDTDTGALLFIGRILDPSS 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn88Ea	NP_524954.2	SERPIN	39..419	CDD:238101	86/392 (22%)
Serpinf1	NP_808788.1	PEDF	40..415	CDD:239007	91/412 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010