DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn88Ea and Serpinb5

DIOPT Version :9

Sequence 1:	NP_524954.2	Gene:	Spn88Ea / 49804	FlyBaseID:	FBgn0028984	Length:	427	Species:	Drosophila melanogaster
Sequence 2:	NP_001347782.1	Gene:	Serpinb5 / 20724	MGIID:	109579	Length:	375	Species:	Mus musculus

Alignment Length:	408	Identity:	108/408 - (26%)
Similarity:	201/408 - (49%)	Gaps:	71/408 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 FAVSMLNVIRQSTPNENVFFSPYSTYHALLLAYFGSSGDTEKELAKVLHLDWADSKEV------- 100
            |||.:...:.:..|..|:.|||.....:|.||..|:.|||..|:.:|||.:  :.|:|
Mouse    11 FAVDLFKQLCERDPAGNILFSPICLSTSLSLAQVGTKGDTANEIGQVLHFE--NVKDVPFGFQTV 73

  Fly   101 ------VRSAYILEKMNRK--ERQSKMPLEFSSADRIFFANDLHVTECARNRLAEEVQQIDFKSQ 157
                  :.|.|.|:.:.|.  ::......||.|:              .:...|:|::.:|||.:
Mouse    74 TSDVNKLSSFYSLKLVKRLYIDKSLNPSTEFISS--------------TKRPYAKELETVDFKDK 124

  Fly   158 TEESRKQINDWIAKQTHDQIRNMLSADEITPRTRLVLANAAYLKGQWLSQFKTEKTVPMPFYTSP 222
            .||::.|||..|.:.|.....::||.:.|:.:|::::.||||..|:|:.:|...:|...||..|.
Mouse   125 LEETKGQINSSIKELTDGHFEDILSENSISDQTKILVVNAAYFVGKWMKKFPESETKECPFRISK 189

  Fly   223 SNYSLVSMMQQKGTFLL-NVDEQLRAHVLQLPYRTVFESQEKEDSSPDENSDISMVLILP---PF 283
            ::...|.||..:.||.| |:|: :...:::||:               :|..:||:::||   ..
Mouse   190 TDTKPVQMMNLEATFCLGNIDD-ISCKIIELPF---------------QNKHLSMLIVLPKDVED 238

  Fly   284 NSNSLEDVLSRLNADSLDDSLKQAMP-----REIEVSLPKFEFEQRLELNPILAKMGVSKMFDES 343
            .|..||.:..:||.::|   |:...|     .::::|||||:.|:.::....|..:|:..:|:||
Mouse   239 ESTGLEKIEQQLNPETL---LQWTNPSTMANAKVKLSLPKFKVEKMIDPKASLESLGLKSLFNES 300

  Fly   344 VATFDDLTSET--ISIGDSKHVAKIKVDEEG--STAAAATVLFTYRSARPVEPAKFECNHPFLFV 404
            .:.|..: |||  :|:.:..|...:::.|:|  |.....:.:..::.       :|..:|||:::
Mouse   301 TSDFSGM-SETKGVSLSNVIHRVCLEITEDGGESIEVPGSRILQHKD-------EFNADHPFIYI 357

  Fly   405 IYDRTSRSILFTGIYRDP 422
            |....:|:|:|.|.:..|
Mouse   358 IRHNKTRNIIFFGKFCSP 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn88Ea	NP_524954.2	SERPIN	39..419	CDD:238101	107/403 (27%)
Serpinb5	NP_001347782.1	maspin_like	4..375	CDD:239012	107/406 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920