Protein Alignment Spn88Ea and SERPINB1

DIOPT Version :9

• Sequence 1: NP_524954.2
• Gene: Spn88Ea / 49804
• FlyBaseID: FBgn0028984
• Length: 427
• Species: Drosophila melanogaster
• Sequence 2: NP_109591.1
• Gene: SERPINB1 / 1992
• HGNCID: 3311
• Length: 379
• Species: Homo sapiens
• Alignment Length: 414
• Identity: 125/414 - (30%)
• Similarity: 198/414 - (47%)
• Gaps: 65/414 - (15%)

  Fly    36 LYKGQQNFAVSMLNVIRQSTPNENVFFSPYSTYHALLLAYFGSSGDTEKELAKVLHLDWADSKEV 100
            |......||:.:...:.::.|..|:|.||:|...|:.:.:.|:.|:|..:|:|..|.   ::.|.
Human     4 LSSANTRFALDLFLALSENNPAGNIFISPFSISSAMAMVFLGTRGNTAAQLSKTFHF---NTVEE 65

  Fly   101 VRS--------------AYILEKMNR---KERQSKMPLEFSSADRIFFANDLHVTECARNRLAEE 148
            |.|              :|||:..||   ::..:.:| ||..:.:..:..||
Human    66 VHSRFQSLNADINKRGASYILKLANRLYGEKTYNFLP-EFLVSTQKTYGADL------------- 116

  Fly   149 VQQIDFKSQTEESRKQINDWIAKQTHDQIRNMLSADEITPRTRLVLANAAYLKGQWLSQFKTEKT 213
             ..:||:..:|::||.||.|:..||..:|..:|::..:...|:|||.||.|.||.|..:|..|.|
Human   117 -ASVDFQHASEDARKTINQWVKGQTEGKIPELLASGMVDNMTKLVLVNAIYFKGNWKDKFMKEAT 180

  Fly   214 VPMPFYTSPSNYSLVSMMQQKGTFLLNVDEQLRAHVLQLPYRTVFESQEKEDSSPDENSDISMVL 278
            ...||..:..:...|.||.||..|.....|.|:..||:|||               :..::|||:
Human   181 TNAPFRLNKKDRKTVKMMYQKKKFAYGYIEDLKCRVLELPY---------------QGEELSMVI 230

  Fly   279 ILP---PFNSNSLEDVLSRLNADSLDDSLKQAMPR-----EIEVSLPKFEFEQRLELNPILAKMG 335
            :||   ...|..|:.:..:|..:.|.:..|   |.     |:.||||:|:.|:...||..||::|
Human   231 LLPDDIEDESTGLKKIEEQLTLEKLHEWTK---PENLDFIEVNVSLPRFKLEESYTLNSDLARLG 292

  Fly   336 VSKMFDESVATFDDLT-SETISIGDSKHVAKIKVDEEGSTAAAATV-LFTYRSARPVEPAKFECN 398
            |..:|:.|.|....:: :..|.|....|.:.::|:|||:.|||||. :.|:....|.|  .|..:
Human   293 VQDLFNSSKADLSGMSGARDIFISKIVHKSFVEVNEEGTEAAAATAGIATFCMLMPEE--NFTAD 355

  Fly   399 HPFLFVIYDRTSRSILFTGIYRDP 422
            |||||.|...:|.||||.|.:..|
Human   356 HPFLFFIRHNSSGSILFLGRFSSP 379

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spn88Ea	NP_524954.2	SERPIN	39..419	CDD:238101	123/406 (30%)
SERPINB1	NP_109591.1	SERPIN	4..379	CDD:294093	124/412 (30%)
		CARD-binding motif (CBM). /evidence=ECO:0000269|PubMed:30692621	351..379		13/27 (48%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BBFJ
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920