DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spn88Ea and SERPINA12

DIOPT Version :9

Sequence 1:	NP_524954.2	Gene:	Spn88Ea / 49804	FlyBaseID:	FBgn0028984	Length:	427	Species:	Drosophila melanogaster
Sequence 2:	NP_001291390.1	Gene:	SERPINA12 / 145264	HGNCID:	18359	Length:	414	Species:	Homo sapiens

Alignment Length:	453	Identity:	113/453 - (24%)
Similarity:	197/453 - (43%)	Gaps:	93/453 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 AIALAGLCGVEPDAGLL------------------DQRL---NLYKGQQNFAVSMLNVIRQSTPN 57
            ||.||.|..|:   |||                  .||:   .|.:...:....:|..:....|.
Human     8 AIFLAVLLTVK---GLLKPSFSPRNYKALSEVQGWKQRMAAKELARQNMDLGFKLLKKLAFYNPG 69

  Fly    58 ENVFFSPYSTYHALLLAYFGSSGDT--------------EKELAKVLHLDWADSKEVVRSAYILE 108
            .|:|.||.|...|..:...|:...|              ||:|.:..|             ||:.
Human    70 RNIFLSPLSISTAFSMLCLGAQDSTLDEIKQGFNFRKMPEKDLHEGFH-------------YIIH 121

  Fly   109 KMNRKERQSKMPLEFSSADRIFFANDLH----VTECARNRLAEEVQQIDFKSQTEESRKQINDWI 169
            ::.:|.:.    |:.|..:.:|....|.    ..|.|:|..:.|....:|:: .|.::|||||:|
Human   122 ELTQKTQD----LKLSIGNTLFIDQRLQPQRKFLEDAKNFYSAETILTNFQN-LEMAQKQINDFI 181

  Fly   170 AKQTHDQIRNMLSADEITPRTRLVLANAAYLKGQWLSQFKTEKTVPMPFYTSPSNYSLVSMMQQK 234
            :::||.:|.|::  :.|.|.|.::|||..:.:.:|..:|....|....|:...::...|.||.:.
Human   182 SQKTHGKINNLI--ENIDPGTVMLLANYIFFRARWKHEFDPNVTKEEDFFLEKNSSVKVPMMFRS 244

  Fly   235 GTFLLNVDEQLRAHVLQLPYRTVFESQEKEDSSPDENSDISMVLILPPFNSNSLEDVLSRLNADS 299
            |.:.:..|::|...:|::||:                .:|:.:.|||  :...|:.:...|..|:
Human   245 GIYQVGYDDKLSCTILEIPYQ----------------KNITAIFILP--DEGKLKHLEKGLQVDT 291

  Fly   300 LDDSLKQAMPREIEVSLPKFEFEQRLELNPILAKMGVSKMFDESVATFDDLTS----ETISIGDS 360
            ..........|.::||:|:.......:|...|:.:||||:|:|    ..|||.    .::.:|::
Human   292 FSRWKTLLSRRVVDVSVPRLHMTGTFDLKKTLSYIGVSKIFEE----HGDLTKIAPHRSLKVGEA 352

  Fly   361 KHVAKIKVDEEGSTAAAATVLFTYRSARPVE-PAKFECNHPFLFVIYDRTSRSILFTGIYRDP 422
            .|.|::|:||.|:..||.|...|.    |:| |...:.:.|:|.:||.....|:||.|...:|
Human   353 VHKAELKMDERGTEGAAGTGAQTL----PMETPLVVKIDKPYLLLIYSEKIPSVLFLGKIVNP 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn88Ea	NP_524954.2	SERPIN	39..419	CDD:238101	100/402 (25%)
SERPINA12	NP_001291390.1	serpinA12_vaspin	40..411	CDD:381026	103/416 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010