Protein Alignment Spn88Ea and SERPINA12

DIOPT Version :10

• Sequence 1: NP_524954.2
• Gene: Spn88Ea / 49804
• FlyBaseID: FBgn0028984
• Length: 427
• Species: Drosophila melanogaster
• Sequence 2: NP_776249.1
• Gene: SERPINA12 / 145264
• HGNCID: 18359
• Length: 414
• Species: Homo sapiens
• Alignment Length: 453
• Identity: 113/453 - (24%)
• Similarity: 197/453 - (43%)
• Gaps: 93/453 - (20%)

  Fly    14 AIALAGLCGVEPDAGLL------------------DQRL---NLYKGQQNFAVSMLNVIRQSTPN 57
            ||.||.|..|:   |||                  .||:   .|.:...:....:|..:....|.
Human     8 AIFLAVLLTVK---GLLKPSFSPRNYKALSEVQGWKQRMAAKELARQNMDLGFKLLKKLAFYNPG 69

  Fly    58 ENVFFSPYSTYHALLLAYFGSSGDT--------------EKELAKVLHLDWADSKEVVRSAYILE 108
            .|:|.||.|...|..:...|:...|              ||:|.:..|             ||:.
Human    70 RNIFLSPLSISTAFSMLCLGAQDSTLDEIKQGFNFRKMPEKDLHEGFH-------------YIIH 121

  Fly   109 KMNRKERQSKMPLEFSSADRIFFANDLH----VTECARNRLAEEVQQIDFKSQTEESRKQINDWI 169
            ::.:|.:.    |:.|..:.:|....|.    ..|.|:|..:.|....:|:: .|.::|||||:|
Human   122 ELTQKTQD----LKLSIGNTLFIDQRLQPQRKFLEDAKNFYSAETILTNFQN-LEMAQKQINDFI 181

  Fly   170 AKQTHDQIRNMLSADEITPRTRLVLANAAYLKGQWLSQFKTEKTVPMPFYTSPSNYSLVSMMQQK 234
            :::||.:|.|::  :.|.|.|.::|||..:.:.:|..:|....|....|:...::...|.||.:.
Human   182 SQKTHGKINNLI--ENIDPGTVMLLANYIFFRARWKHEFDPNVTKEEDFFLEKNSSVKVPMMFRS 244

  Fly   235 GTFLLNVDEQLRAHVLQLPYRTVFESQEKEDSSPDENSDISMVLILPPFNSNSLEDVLSRLNADS 299
            |.:.:..|::|...:|::||:                .:|:.:.|||  :...|:.:...|..|:
Human   245 GIYQVGYDDKLSCTILEIPYQ----------------KNITAIFILP--DEGKLKHLEKGLQVDT 291

  Fly   300 LDDSLKQAMPREIEVSLPKFEFEQRLELNPILAKMGVSKMFDESVATFDDLTS----ETISIGDS 360
            ..........|.::||:|:.......:|...|:.:||||:|:|    ..|||.    .::.:|::
Human   292 FSRWKTLLSRRVVDVSVPRLHMTGTFDLKKTLSYIGVSKIFEE----HGDLTKIAPHRSLKVGEA 352

  Fly   361 KHVAKIKVDEEGSTAAAATVLFTYRSARPVE-PAKFECNHPFLFVIYDRTSRSILFTGIYRDP 422
            .|.|::|:||.|:..||.|...|.    |:| |...:.:.|:|.:||.....|:||.|...:|
Human   353 VHKAELKMDERGTEGAAGTGAQTL----PMETPLVVKIDKPYLLLIYSEKIPSVLFLGKIVNP 411

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spn88Ea	NP_524954.2	serpin_crustaceans_chelicerates_insects	36..422	CDD:381059	101/408 (25%)
SERPINA12	NP_776249.1	serpinA12_vaspin	40..411	CDD:381026	103/416 (25%)
		Reactive center loop. /evidence=ECO:0000269|PubMed:26529565, ECO:0000305|PubMed:23370777, ECO:0000305|PubMed:26199422	364..382		7/21 (33%)