DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn88Ea and Serpini1

DIOPT Version :9

Sequence 1:	NP_524954.2	Gene:	Spn88Ea / 49804	FlyBaseID:	FBgn0028984	Length:	427	Species:	Drosophila melanogaster
Sequence 2:	NP_446231.1	Gene:	Serpini1 / 116459	RGDID:	619896	Length:	410	Species:	Rattus norvegicus

Alignment Length:	434	Identity:	120/434 - (27%)
Similarity:	201/434 - (46%)	Gaps:	51/434 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 MAVLPAIALAGLCGVEPDAGLLDQRLNLYKGQQNFAVSMLNVIRQSTPNENVFFSPYSTYHALLL 73
            ||.|..::|..|..:...|...|:.:      ..::|::.|.:|.:..:||:.|||.|...|:.:
  Rat     1 MAYLGLLSLVALQSLVTGAAFPDETI------AEWSVNVYNHLRATGEDENILFSPLSIALAMGV 59

  Fly    74 AYFGSSGDTEKELAKVLHLDWADSKEVVRSAYILEKM-NRKERQSKMPLEFSSADRIFFANDLHV 137
            ...|:.|.|.||:...:..:...|.|..........| :.:|.|..|.:    |:.:|..|..|:
  Rat    60 MELGAQGSTLKEIRHSMGYESLKSGEEFSFLRDFSSMVSAEEGQYVMKI----ANSLFVQNGFHI 120

  Fly   138 TE----CARNRLAEEVQQIDFKSQTEESRKQINDWIAKQTHDQIRNMLSADEITPRTRLVLANAA 198
            .|    ..:.....||..:|| |:.......||.|:...|:..:::::|..:....|.|.|.||.
  Rat   121 NEEFLQMMKMYFNAEVNHVDF-SENVAVANYINKWVENYTNSLLKDLVSPGDFDAVTHLALINAV 184

  Fly   199 YLKGQWLSQFKTEKTVPMPFYTSPSNYSLVSMMQQKGTFLLN--VDEQLRA----HVLQLPYRTV 257
            |.||.|.|||:.|.|....|.....:...:.||.|:|.|...  .|....|    .||::||
  Rat   185 YFKGNWKSQFRPENTRTFSFTKDDESEVQIPMMYQQGEFYYGEFSDGSNEAGGIYQVLEIPY--- 246

  Fly   258 FESQEKEDSSPDENSDISMVLILP----PFNSNSLEDVLSRLNADSLDDSLKQAMPREIEVSLPK 318
                        |..:|||:|:|.    |.  .:||.:|.....:...:|:|:   :::||.||:
  Rat   247 ------------EGDEISMMLVLSRQEVPL--ATLEPLLKPQLIEEWANSVKK---QKVEVYLPR 294

  Fly   319 FEFEQRLELNPILAKMGVSKMF--DESVATFDDLTSETISIGDSKHVAKIKVDEEGSTAAAATVL 381
            |..||.::|..||..:||:::|  |.::....|  .:.:.:..:.|.:.|:|:||||.||.|:.:
  Rat   295 FTVEQEIDLKDILKALGVTEIFIKDANLTAMSD--KKELFLSKAVHKSFIEVNEEGSEAAVASGM 357

  Fly   382 FTYRSARPVEPAKFECNHPFLFVIYDRTSRSILFTGIYRDPKTI 425
            ........:.| :...:|||||:|.:|.:.:|||.|....|:|:
  Rat   358 IAISRMAVLFP-QVIVDHPFLFLIKNRKTGTILFMGRVMHPETM 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn88Ea	NP_524954.2	SERPIN	39..419	CDD:238101	111/396 (28%)
Serpini1	NP_446231.1	neuroserpin	23..410	CDD:239003	114/412 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BBFJ
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920