DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn88Ea and serpine1

DIOPT Version :9

Sequence 1:	NP_524954.2	Gene:	Spn88Ea / 49804	FlyBaseID:	FBgn0028984	Length:	427	Species:	Drosophila melanogaster
Sequence 2:	NP_001108031.1	Gene:	serpine1 / 100136840	ZFINID:	ZDB-GENE-070912-60	Length:	384	Species:	Danio rerio

Alignment Length:	435	Identity:	117/435 - (26%)
Similarity:	195/435 - (44%)	Gaps:	75/435 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SISLMAVLPAIALAGLCGVEPDAGLLDQRLNLYKGQQNFAVSMLNVIRQSTPNENVFFSPYSTYH 69
            |:|::.:. |:..:.||.:..|.            |.:|.:.:.....||.|:.|:..|||....
Zfish     3 SLSVLLIF-ALCASSLCNLIQDK------------QTDFGLQVFAEAVQSAPDRNLALSPYGIAS 54

  Fly    70 ALLLAYFGSSGDTEKELAKVLHLDWADSKEVVRSAYILEKMNRKERQSKMPLEFSSADRIFFAND 134
            .|.:|..|:.|.|.|.||.             :..|.|::....:.|..:..:.:|.|.:..|:.
Zfish    55 VLGMAQMGAYGATLKLLAS-------------KMGYSLQERGMPKLQRLLQRDLASEDGVEVASG 106

  Fly   135 LHV------TECARNRLAEEVQ----QIDFKSQTEESRKQINDWIAKQTHDQIRNMLSADEITPR 189
            :.|      .:..|..|::..|    |||| ||.|.:|:.||.|.:..|...|...|.:..::..
Zfish   107 VMVDRKIILEKVFRRSLSKAFQSVPHQIDF-SQPEMARQVINSWTSDHTDGMISEFLPSGVLSEL 170

  Fly   190 TRLVLANAAYLKGQWLSQFKTEKTVPMPFYTSPSNYSLVSMMQQKGTFLLNVDEQLRA-----HV 249
            ||||..||.:..|.|.:.|....|....|:|  .|.|.||:.....|...|..|.:..     .|
Zfish   171 TRLVFLNALHFHGVWKTPFDPRNTREQLFHT--VNGSAVSVPMMTTTQKFNYGEFVSKDGVDYDV 233

  Fly   250 LQLPYRTVFESQEKEDSSPDENSDISMVLILPPFNSNSLEDV-LSRLNADSLDDSL---KQAMPR 310
            :::||               |...|||:|: .||.    :|| ||.||.:.....:   :|.| |
Zfish   234 IEMPY---------------EGESISMLLV-TPFE----KDVPLSALNKELSSSRIHQWRQEM-R 277

  Fly   311 EI--EVSLPKFEFEQRLELNPILAKMGVSKMFDESVATFDDLTS-ETISIGDSKHVAKIKVDEEG 372
            :|  ::|:|:|..:..::|...|::||:..:|.:|.|.|..:|: |.:.:.......|::|:|||
Zfish   278 KISKQLSIPRFSMDTEIDLKSTLSRMGLGDIFSQSRADFSRITTEEPLCVSKVLQRVKLEVNEEG 342

  Fly   373 STAAAATVLFTYRSARPVEPAKFECNHPFLFVIYDRTSRSILFTG 417
            :..::||....| |...||  :...:.||.|:|..:.:.::||:|
Zfish   343 TKGSSATAAVIY-SRMAVE--EITLDRPFFFLIQHKPTGALLFSG 384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn88Ea	NP_524954.2	SERPIN	39..419	CDD:238101	111/401 (28%)
serpine1	NP_001108031.1	SERPIN	26..384	CDD:294093	109/397 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.020