DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn88Ea and serpina10b

DIOPT Version :9

Sequence 1:	NP_524954.2	Gene:	Spn88Ea / 49804	FlyBaseID:	FBgn0028984	Length:	427	Species:	Drosophila melanogaster
Sequence 2:	XP_009291625.1	Gene:	serpina10b / 100003661	ZFINID:	ZDB-GENE-100716-5	Length:	395	Species:	Danio rerio

Alignment Length:	437	Identity:	122/437 - (27%)
Similarity:	203/437 - (46%)	Gaps:	75/437 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 VLPAIALAGLCGVE------PDAGLL-----DQRLNLYKGQQNFAVSMLNVIRQSTPNENVFFSP 64
            :|..|:...||..|      ||...|     |..:|||:     .:|.|:       :.||.|||
Zfish     6 LLVFISACFLCSAEHEELRTPDISDLAFRNTDFAINLYR-----KISSLH-------DRNVVFSP 58

  Fly    65 YST---YHALLLAYFGSSGDTEKELAKVLHLDWADSKEVVRSAYILEKMNRKERQSKMPLEFSSA 126
            .|.   :.|||||   :.|.|..|:.|.|:|:..|..:..|...:.:::::     .:.|:....
Zfish    59 LSVSTCFSALLLA---AQGSTRTEILKGLNLEALDGGDSRRVPELFQQLHQ-----NISLQMEQG 115

  Fly   127 DRIFFANDLHV----TECARNRLAEEVQQIDFKSQTEESRKQINDWIAKQTHDQIRNMLSADEIT 187
            ..:|.....|:    ::..:.....||.::|| |:....|..||::::::|..::..||  :.:.
Zfish   116 TALFLDQHFHLQTNFSQQIQRFFNAEVLRVDF-SKPAVCRSLINEFVSRKTGRKVLEML--ESVE 177

  Fly   188 PRTRLVLANAAYLKGQWLSQFKTEKTVPMPFYTSPSNYSLVSMMQQKGTFLLNVDEQLRAHVLQL 252
            |.|:::|.|..:.||.|...|....|....||....|...|.||..:..|.:..|..|||.||:|
Zfish   178 PLTQMLLLNTIFYKGDWERPFNPNNTEKSRFYVDKYNIVQVPMMMLEEKFSVVEDRDLRARVLRL 242

  Fly   253 PYRTVFESQEKEDSSPDENSDISMVLILPPFNSN--SLEDVLSRLNADSLDDSLKQAMPREIEVS 315
            |||                ...||:::||..:::  ::||.:|   |:.|...:|.....::||.
Zfish   243 PYR----------------GGASMLILLPSADADYTAIEDEIS---AERLHGWIKNMRRMKMEVH 288

  Fly   316 LPKFEFEQRLELNPILAKMGVSKMFDESVATFDDLTSET----ISIGDSKHVAKIKVDEEGSTAA 376
            ||:|..:|...::.:|.::|:|.:|.:|.    |||..:    :.:....|.|.|:|.|:|::||
Zfish   289 LPRFRMDQSYHMHELLPQLGISSVFQDSA----DLTGLSRDAHLKVSQVLHKAVIEVYEQGTSAA 349

  Fly   377 AAT-VLFTYRSARPVEPAKFECNHPFLFVIYDRTSRSILFTGIYRDP 422
            ::| |..|..|.    |..|..|.||.|.:|...:.|:||.|...||
Zfish   350 SSTSVGITAYSL----PDTFIINRPFFFFLYHEETASLLFMGRVIDP 392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn88Ea	NP_524954.2	SERPIN	39..419	CDD:238101	108/393 (27%)
serpina10b	XP_009291625.1	Serpin	35..392	CDD:278507	112/406 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910