DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn55B and SERPINB11

DIOPT Version :9

Sequence 1:	NP_524953.1	Gene:	Spn55B / 49803	FlyBaseID:	FBgn0028983	Length:	374	Species:	Drosophila melanogaster
Sequence 2:	NP_001357404.1	Gene:	SERPINB11 / 89778	HGNCID:	14221	Length:	392	Species:	Homo sapiens

Alignment Length:	388	Identity:	120/388 - (30%)
Similarity:	199/388 - (51%)	Gaps:	45/388 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 FTSELFQLLSAGGLKENVVFSPFSIQTCIALAFAGSQGETADEIAKALHFV-------------- 65
            |..::|:.|::..:.:|:.||..|:...:::...|::|||.:::.|.|||.
Human    11 FCLDVFKELNSNNIGDNIFFSSLSLLYALSMVLLGARGETEEQLEKVLHFSHTVDSLKPGFKDSP 75

  Fly    66 ---------SNFPPEVAQTFQFVLEKYRNSN-LLRVANKLYVQEGKQLKPAYQSAIKEQYHSEAE 120
                     |.|..|.:|..|      .:|| .|.:||:||..:.......|.|..::.|.:..:
Human    76 KCSQAGRIHSEFGVEFSQINQ------PDSNCTLSIANRLYGTKTMAFHQQYLSCSEKWYQARLQ 134

  Fly   121 SINFALN-DAAAQAINAWVNAKTQGKITELVSADSFSDNTRLVLLNALHFKGSWAHKFSEERTEE 184
            :::|..: :...:.|||||..||.||:..|....:...::.:||:||::|||.|.:||....|.:
Human   135 TVDFEQSTEETRKTINAWVENKTNGKVANLFGKSTIDPSSVMVLVNAIYFKGQWQNKFQVRETVK 199

  Fly   185 DIFWVGEEEQVKINYMNQKAKFNYGFFEDLGCTALEMPYQDSDLSMFVLLPQERTGIYALAEKLK 249
            ..|.:.|.:.|.:..|.|...|...|.::.....||:||.::.|||.:|||   .||..|.:..|
Human   200 SPFQLSEGKNVTVEMMYQIGTFKLAFVKEPQMQVLELPYVNNKLSMIILLP---VGIANLKQIEK 261

  Fly   250 TVNLVDL-----ADKLTVEEVHVKFPKFKVDYSLELAEKLKQLGITKMFTD-QAEFSNLLESP-E 307
            .:|....     :..:...||.|..|:||::...||...||.||:|.:|.. :|:.|.:  || :
Human   262 QLNSGTFHEWTSSSNMMEREVEVHLPRFKLETKYELNSLLKSLGVTDLFNQVKADLSGM--SPTK 324

  Fly   308 GVFVSKVLHKATIEVNEEGTEAAAATGMIMMTRMMTFPLQFQADRPFLYVI--WNKKNILFAG 368
            |:::||.:||:.::|:|||||||||||..:..:.:....||:|:.|||:.|  .:...|||.|
Human   325 GLYLSKAIHKSYLDVSEEGTEAAAATGDSIAVKSLPMRAQFKANHPFLFFIRHTHTNTILFCG 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn55B	NP_524953.1	SERPIN	13..370	CDD:238101	120/388 (31%)
SERPINB11	NP_001357404.1	ovalbumin_like	4..392	CDD:239014	120/388 (31%)
SERPINB11	NP_001357404.1	RCL. /evidence=ECO:0000250	341..365		11/23 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	232	1.000	Domainoid score	I2423
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	233	1.000	Inparanoid score	I3423
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	1	1.000	-	-		mtm8652
orthoMCL	1	0.900	-	-		OOG6_100128
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R10598
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.910