DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn55B and SERPINB12

DIOPT Version :9

Sequence 1:	NP_524953.1	Gene:	Spn55B / 49803	FlyBaseID:	FBgn0028983	Length:	374	Species:	Drosophila melanogaster
Sequence 2:	XP_005266835.2	Gene:	SERPINB12 / 89777	HGNCID:	14220	Length:	437	Species:	Homo sapiens

Alignment Length:	412	Identity:	124/412 - (30%)
Similarity:	203/412 - (49%)	Gaps:	58/412 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 RFTSELFQLLSAGGLKENVVFSPFSIQTCIALAFAGSQGETADEIAKALHF------VSNFP-PE 71
            :|..:|||.:......:|:.|||.|:...:.:...|::.::|.:|.:.|||      .|..| |.
Human    22 KFCFDLFQEIGKDDRHKNIFFSPLSLSAALGMVRLGARSDSAHQIDEVLHFNEFSQNESKEPDPC 86

  Fly    72 VAQTFQFV----------------------------------------LEKYRNSNLLRVANKLY 96
            :....|.|                                        |::.:....|.:||:||
Human    87 LKSNKQKVLADSSLEGQKKTTEPLDQQAGSLNNESGLVSCYFGQLLSKLDRIKTDYTLSIANRLY 151

  Fly    97 VQEGKQLKPAYQSAIKEQYHSEAESINFALN-DAAAQAINAWVNAKTQGKITELVSADSFSDNTR 160
            .::...:...|...:.:.||:..||::|..| :.:.|.||.||..::||||.||.|.|:.:..|.
Human   152 GEQEFPICQEYLDGVIQFYHTTIESVDFQKNPEKSRQEINFWVECQSQGKIKELFSKDAINAETV 216

  Fly   161 LVLLNALHFKGSWAHKFSEERTEEDIFWVGEEEQVKINYMNQKAKFNYGFFEDLGCTALEMPYQD 225
            |||:||::||..|...|..|.|.:..|.:...|...:..|.||..:..||.|::....|||.|..
Human   217 LVLVNAVYFKAKWETYFDHENTVDAPFCLNANENKSVKMMTQKGLYRIGFIEEVKAQILEMRYTK 281

  Fly   226 SDLSMFVLLPQER----TGIYALAEKLKTVNLV--DLADKLTVEEVHVKFPKFKVDYSLELAEKL 284
            ..||||||||...    .|:..|..|:....:|  ..::.::.|.|.:.||:|.::.|.:|...|
Human   282 GKLSMFVLLPSHSKDNLKGLEELERKITYEKMVAWSSSENMSEESVVLSFPRFTLEDSYDLNSIL 346

  Fly   285 KQLGITKMFTD-QAEFSNLLESPEGVFVSKVLHKATIEVNEEGTEAAAATGMIMMTRMMTFPLQF 348
            :.:|||.:|.: :|:.:.:..|| .:::||::||..:||:|.||:||||||.::..|.:...::|
Human   347 QDMGITDIFDETRADLTGISPSP-NLYLSKIIHKTFVEVDENGTQAAAATGAVVSERSLRSWVEF 410

  Fly   349 QADRPFLYVIWNKK--NILFAG 368
            .|:.|||:.|.:.|  .|||.|
Human   411 NANHPFLFFIRHNKTQTILFYG 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn55B	NP_524953.1	SERPIN	13..370	CDD:238101	124/412 (30%)
SERPINB12	XP_005266835.2	ovalbumin_like	16..437	CDD:239014	124/412 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BBFJ
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	1	1.000	-	-		mtm8652
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.830