DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn55B and Serpind1

DIOPT Version :9

Sequence 1:	NP_524953.1	Gene:	Spn55B / 49803	FlyBaseID:	FBgn0028983	Length:	374	Species:	Drosophila melanogaster
Sequence 2:	NP_077358.1	Gene:	Serpind1 / 79224	RGDID:	619854	Length:	479	Species:	Rattus norvegicus

Alignment Length:	386	Identity:	112/386 - (29%)
Similarity:	196/386 - (50%)	Gaps:	43/386 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 ARFTSELFQLL-SAGGLKENVVFSPFSIQTCIALAFAGSQGETADEIAKALHFVSNFPPEVAQTF 76
            |:|...|:::| ......:|:..:|..|.|.:.:...|.:|||.:|:...|||         :.|
  Rat   111 AKFAFNLYRVLKDQATSSDNIFIAPVGISTAMGMISLGLRGETHEEVHSVLHF---------KDF 166

  Fly    77 QFVLEKYRNSNL-------------------LRVANKLYVQEGKQLKPAYQSAIKEQYHSEAESI 122
            .....||..:.:                   |:..|.||:|:...::..:::|::|.|.:||:..
  Rat   167 VNASSKYEVTTIHNLFRKLTHRLFRRNFGYTLQSVNDLYIQKQFPIREDFKAAMREFYFAEAQEA 231

  Fly   123 NFALNDAAAQAINAWVNAKTQGKITE-LVSADSFSDNTRLVLLNALHFKGSWAHKFSEERTEEDI 186
            :|: :.|.....|:.:...|:|.|.| |.:.||   .|::::||.::|||:|.:||..|.|....
  Rat   232 DFS-DPAFISKANSHILKLTKGLIKEALENTDS---ATQMMILNCIYFKGAWMNKFPVEMTHNHN 292

  Fly   187 FWVGEEEQVKINYMNQKAKFNYGFFEDLGCTALEMPYQDSDLSMFVLLPQERTGIYALAEKLKTV 251
            |.:.|.|.||::.|..|..|.....::|.|..|::.|. ..:||.:::|::.:|:..|..:| |.
  Rat   293 FRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYV-GGISMLIVIPRKLSGMKTLEAQL-TP 355

  Fly   252 NLVDLADK-LTVEEVHVKFPKFKVDYSLELAEKLKQLGITKMFTDQAEFSNLLESPEGVFVSKVL 315
            .:|:...| :|.....|..||||::.:..|.|.||.:||||:|......|.:  |.:.:.:....
  Rat   356 QVVERWQKSMTNRTREVLLPKFKLEKNYNLVEVLKSMGITKLFNKNGNMSGI--SDQRIIIDLFK 418

  Fly   316 HKATIEVNEEGTEAAAATGMIMMTRMMTFPLQFQADRPFLYVIWNKKN--ILFAGAFVKAA 374
            |::||.||||||:|||.|.:..|.  ::..::|..|||||::::..:.  :||.|.....|
  Rat   419 HQSTITVNEEGTQAAAVTTVGFMP--LSTQVRFTVDRPFLFLVYEHRTSCLLFMGRVANPA 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn55B	NP_524953.1	SERPIN	13..370	CDD:238101	111/380 (29%)
Serpind1	NP_077358.1	HCII	44..477	CDD:239002	111/384 (29%)
		2 X 11 AA approximate repeats, Asp/Glu-rich (acidic) (hirudin-like)	55..79
		Glycosaminoglycan-binding site. /evidence=ECO:0000250	172..192		2/19 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.020