DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn55B and Serpina3a

DIOPT Version :9

Sequence 1:	NP_524953.1	Gene:	Spn55B / 49803	FlyBaseID:	FBgn0028983	Length:	374	Species:	Drosophila melanogaster
Sequence 2:	NP_001161177.1	Gene:	Serpina3a / 74069	MGIID:	1921319	Length:	422	Species:	Mus musculus

Alignment Length:	379	Identity:	108/379 - (28%)
Similarity:	182/379 - (48%)	Gaps:	39/379 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 FTSELFQLLSAGGLKENVVFSPFSIQTCIALAFAGSQGETADEIAKALHFVSNFPPE--VAQTFQ 77
            |...|::.|:.....:|:||||.||...:||...|::..|.:||.:.|.|.....||  :.|.|.
Mouse    56 FAFSLYKKLALKNPHKNIVFSPLSISAALALMSLGAKDNTLEEILEGLKFNLTETPEADIHQNFG 120

  Fly    78 FVLE---KYRNSNLLRVANKLYVQEGKQLKPAYQSAIKEQYHSEAESINFALNDAAAQAINAWVN 139
            .:|:   :..|...:...|.|::.:..|:...::...:..|.:||.:.:|.|...|.:.||.:|.
Mouse   121 HLLQMLIQPENQVQINAGNALFIDKHLQILTEFKEKARALYKAEAFTADFQLPREATKLINDYVR 185

  Fly   140 AKTQGKITELVSADSFSDNTRLVLLNALHFKGSWAHKFSEERTEEDIFWVGEEEQVKINYM-NQK 203
            .:|||||.||||  ....||.:.|:|.|:|:|.|...|..|.|....|.:..:..|.:..| .::
Mouse   186 KQTQGKIKELVS--DLHRNTSMALVNFLNFQGFWNVTFDPEDTFLGNFTLDRKRTVNVPMMKTEE 248

  Fly   204 AKFNYGFFEDLGCTALEMPYQDSDLSMFVLLPQERTGIYALAEKLKTVNL----VDLADKLTVEE 264
            ...||...|::..|.:|:.|..:...:|:|..|.|  |..:.:.|:..:|    ..|..::..|
Mouse   249 LTTNYFRDEEMQSTVMELNYIGNASFLFILPDQGR--IQHVEDSLQPQSLRKWRKSLRPRMLDE- 310

  Fly   265 VHVKFPKFKVDYSLELAEKLKQLGITKMFTDQAEFSNLLESPEGVFVSKVLHKATIEVNEEGTEA 329
              :..|||.:.....|.:.|.:|||.::|:.||:.|. :...:.:.||:::|:|.::|.|..|||
Mouse   311 --LSLPKFSLSQDYNLNDILPELGIKEVFSTQADLSG-ITGAKNIRVSQMIHQAALDVTETHTEA 372

  Fly   330 AAATGMIMMTRMMTFPLQFQA----------DRPFLYVIWNK--KNILFAGAFV 371
                .:|.:.|     ..||:          ||.|||:|.:.  |:|...|..:
Mouse   373 ----DVITIAR-----YNFQSAKIKAKIVKVDREFLYLILDPMFKSISVMGKVI 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn55B	NP_524953.1	SERPIN	13..370	CDD:238101	108/376 (29%)
Serpina3a	NP_001161177.1	SERPIN	53..416	CDD:294093	108/376 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.010