DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn55B and SERPINA7

DIOPT Version :9

Sequence 1:	NP_524953.1	Gene:	Spn55B / 49803	FlyBaseID:	FBgn0028983	Length:	374	Species:	Drosophila melanogaster
Sequence 2:	XP_006724746.1	Gene:	SERPINA7 / 6906	HGNCID:	11583	Length:	425	Species:	Homo sapiens

Alignment Length:	396	Identity:	122/396 - (30%)
Similarity:	195/396 - (49%)	Gaps:	50/396 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 FDFNLEFARGGARFTSELFQLLSAGGLKENVVFSPFSIQTCIALAFAGSQGETADEIAKALHFVS 66
            |.|||.     .|||.|.        ..:|:.|||.||...:.:...|:...|..||.:.|.|..
Human    49 FAFNLY-----RRFTVET--------PDKNIFFSPVSISAALVMLSFGACCSTQTEIVETLGFNL 100

  Fly    67 NFPP--EVAQTFQFVL--EKYRNSNL-LRVANKLYVQEGKQLKP--AYQSAIKEQYHSEAESINF 124
            ...|  |:...||.::  ..:....| |::.|.|::  ||.|||  .:.:.:|..|.:|..|.:|
Human   101 TDTPMVEIQHGFQHLICSLNFPKKELELQIGNALFI--GKHLKPLAKFLNDVKTLYETEVFSTDF 163

  Fly   125 ALNDAAAQAINAWVNAKTQGKITELVSADSFSDNTRLVLLNALHFKGSWAHKFSEERTEE-DIFW 188
            :...||.|.||:.|..:|:||:..|:  .....||.:||:|.:|||..||:.|...:||: ..|.
Human   164 SNISAAKQEINSHVEMQTKGKVVGLI--QDLKPNTIMVLVNYIHFKAQWANPFDPSKTEDSSSFL 226

  Fly   189 VGEEEQVKINYMNQKAKFNYGFFEDLGCTALEMPYQDSDLSMFVLLPQE---RTGIYALAEK-LK 249
            :.:...|::..|:|..::.:....:|.||.|:|.|..:.|::|| ||:|   .:...|::.| ||
Human   227 IDKTTTVQVPMMHQMEQYYHLVDMELNCTVLQMDYSKNALALFV-LPKEGQMESVEAAMSSKTLK 290

  Fly   250 TVNLVDLADKLTVEEVHVKFPKFKVDYSLELAEKLKQLGITKMFTDQAEFSNLLES--------P 306
            ..|.:     |....|.:..|||.:..:.:|...|.::||...:::.|:||.|.|.        |
Human   291 KWNRL-----LQKGWVDLFVPKFSISATYDLGATLLKMGIQHAYSENADFSGLTEDNGLKLSNRP 350

  Fly   307 EG-VFVSKVLHKATIEVNEEGTEAAAATGMIMMTR-MMTF--PLQFQADRPFLYVIWNK--KNIL 365
            .| |..::..|||.:.:.|:||||||...:.:..: ..||  |: .|.||.|:.:|..:  ::||
Human   351 AGFVLPTQAAHKAVLHIGEKGTEAAAVPEVELSDQPENTFLHPI-IQIDRSFMLLILERSTRSIL 414

  Fly   366 FAGAFV 371
            |.|..|
Human   415 FLGKVV 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn55B	NP_524953.1	SERPIN	13..370	CDD:238101	117/382 (31%)
SERPINA7	XP_006724746.1	alpha-1-antitrypsin_like	46..419	CDD:239011	121/393 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.010