Protein Alignment Spn55B and SERPINB3

DIOPT Version :10

• Sequence 1: NP_524953.1
• Gene: Spn55B / 49803
• FlyBaseID: FBgn0028983
• Length: 374
• Species: Drosophila melanogaster
• Sequence 2: NP_008850.1
• Gene: SERPINB3 / 6317
• HGNCID: 10569
• Length: 390
• Species: Homo sapiens
• Alignment Length: 386
• Identity: 137/386 - (35%)
• Similarity: 204/386 - (52%)
• Gaps: 27/386 - (6%)

  Fly     9 ARGGARFTSELFQLLSAGGLKENVVF-SPFSIQTCIALAFAGSQGETADEIAKALHF---VSNFP 69
            :....:|..:|||.....  |||.:| ||.||.:.:.:...|::..||.:|.|.|||   ..|..
Human     5 SEANTKFMFDLFQQFRKS--KENNIFYSPISITSALGMVLLGAKDNTAQQIKKVLHFDQVTENTT 67

  Fly    70 PEVA-----------QTFQFVLEKYRNSN---LLRVANKLYVQEGKQLKPAYQSAIKEQYHSEAE 120
            .:.|           ..||.:|.::..|.   .|::||||:.::.......|..|||:.|.:..|
Human    68 GKAATYHVDRSGNVHHQFQKLLTEFNKSTDAYELKIANKLFGEKTYLFLQEYLDAIKKFYQTSVE 132

  Fly   121 SINFA-LNDAAAQAINAWVNAKTQGKITELVSADSFSDNTRLVLLNALHFKGSWAHKFSEERTEE 184
            |::|| ..:.:.:.||:||.::|..||..|:...:...||.|||:||::|||.|..||::|.|:|
Human   133 SVDFANAPEESRKKINSWVESQTNEKIKNLIPEGNIGSNTTLVLVNAIYFKGQWEKKFNKEDTKE 197

  Fly   185 DIFWVGEEEQVKINYMNQKAKFNYGFFEDLGCTALEMPYQDSDLSMFVLLPQERTGIYALAEKLK 249
            :.||..:.....|..|.|...|::...||:....||:||:..||||.||||.|..|:..|.|||.
Human   198 EKFWPNKNTYKSIQMMRQYTSFHFASLEDVQAKVLEIPYKGKDLSMIVLLPNEIDGLQKLEEKLT 262

  Fly   250 TVNLVDLADKLTVEE--VHVKFPKFKVDYSLELAEKLKQLGITKMFTDQAEFSNLLESPEGVFVS 312
            ...|::......:.|  |.:..|:|||:.|.:|.:.|:.:|:..:|...|:.|.:..| .|:.:|
Human   263 AEKLMEWTSLQNMRETRVDLHLPRFKVEESYDLKDTLRTMGMVDIFNGDADLSGMTGS-RGLVLS 326

  Fly   313 KVLHKATIEVNEEGTEAAAATGMIMMTRMMTFP-LQFQADRPFLYVI-WNKKN-ILFAGAF 370
            .|||||.:||.|||.||||||.::......|.. .:|..:.|||:.| .||.| |||.|.|
Human   327 GVLHKAFVEVTEEGAEAAAATAVVGFGSSPTSTNEEFHCNHPFLFFIRQNKTNSILFYGRF 387

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spn55B	NP_524953.1	serpin42Da-like	15..368	CDD:381065	135/376 (36%)
SERPINB3	NP_008850.1	serpinB3_B4_SCCA1_2	1..390	CDD:381030	137/386 (35%)