DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn55B and Serpinb2

DIOPT Version :9

Sequence 1:	NP_524953.1	Gene:	Spn55B / 49803	FlyBaseID:	FBgn0028983	Length:	374	Species:	Drosophila melanogaster
Sequence 2:	NP_067728.1	Gene:	Serpinb2 / 60325	RGDID:	621823	Length:	416	Species:	Rattus norvegicus

Alignment Length:	414	Identity:	129/414 - (31%)
Similarity:	203/414 - (49%)	Gaps:	53/414 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 EFARGGARFTSELFQLLSAGGLKENVVFSPFSIQTCIALAFAGSQGETADEIAKALHF------- 64
            |.:.....|...|.:.:......:|:..||:||.:.:|:.|.|:|..|.:::||.|:|
  Rat     3 ELSMANTMFALNLLKQIEQSNSTQNIFISPWSISSTLAIVFLGAQANTEEQMAKVLNFDKIGSYD 67

  Fly    65 -------------------VSNFPPEVAQ------------TFQFVLEKYR-NSNLLRVANKLYV 97
                               ..|:|..:.|            :....:...| ...||..||||:.
  Rat    68 LTPGNPENFHGCDFAQHIQRDNYPVAILQAQARDKIHSAFSSLSSTINTPRLGDYLLESANKLFG 132

  Fly    98 QEGKQLKPAYQSAIKEQYHSEAESINF--ALNDAAAQAINAWVNAKTQGKITELVSADSFSDNTR 160
            ::..:.|..|....|:.|.:|.|:::|  ..|: |.:.||:||..:|:|:|..|:...|..::|:
  Rat   133 EKSARFKEEYIQRCKKYYSTEPEAVDFLECANE-ARKKINSWVKTQTKGEIPNLLPEGSVDEDTK 196

  Fly   161 LVLLNALHFKGSWAHKFSEERTEEDIFWVGEEEQVKINYMNQKAKFNYGFFEDLGCTALEMPYQD 225
            :||:|.::|||.|...|.:.......|.|...|...:..|..:.|.|.|:.:||....||:|| .
  Rat   197 MVLVNTIYFKGRWKTPFQKRLNGLYPFRVNLNESKPVQMMYLREKLNIGYIKDLKTQILELPY-I 260

  Fly   226 SDLSMFVLLPQE----RTGIYALAEKLKTVNLVDLADKLTVEE--VHVKFPKFKVDYSLELAEKL 284
            .::|||:|||.|    .||:..|..::...|......|.|::|  |.|..||||:..:.||...|
  Rat   261 GNISMFLLLPDEIEDSSTGLEMLEREINFDNFNKWISKETLDEDDVLVYIPKFKLAQNYELKPIL 325

  Fly   285 KQLGITKMFT-DQAEFSNLLESPEGVFVSKVLHKATIEVNEEGTEAAAATGMIMMTRMMTFPLQF 348
            :::|:...|. .:|:||.:.||.: :|:|:|.|:||::||||||.||..||.:|..|......||
  Rat   326 QRMGMEDAFNKGKADFSGMSESND-LFLSEVFHQATVDVNEEGTVAAGGTGAVMTGRTGHGGPQF 389

  Fly   349 QADRPFLYVIWNK--KNILFAGAF 370
            .||.|||:.|.|.  :.|||.|.|
  Rat   390 VADHPFLFFIMNNITRTILFVGRF 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn55B	NP_524953.1	SERPIN	13..370	CDD:238101	127/406 (31%)
Serpinb2	NP_067728.1	serpinB2_PAI-2	2..416	CDD:381029	129/414 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	228	1.000	Domainoid score	I2400
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	229	1.000	Inparanoid score	I3374
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	1	1.000	-	-		mtm12319
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.980