DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spn55B and SERPINE1

DIOPT Version :9

Sequence 1:	NP_524953.1	Gene:	Spn55B / 49803	FlyBaseID:	FBgn0028983	Length:	374	Species:	Drosophila melanogaster
Sequence 2:	NP_001373389.1	Gene:	SERPINE1 / 5054	HGNCID:	8583	Length:	492	Species:	Homo sapiens

Alignment Length:	395	Identity:	118/395 - (29%)
Similarity:	186/395 - (47%)	Gaps:	65/395 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 FTSELFQLLSAGGLKENVVFSPFSIQTCIALAFAGSQGETADEIAKALHFV---SNFPPEVAQTF 76
            |...:||.::......||||||:.:.:.:|:....:.|||..:|..|:.|.   ....|.:...:
Human    38 FGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLY 102

  Fly    77 QFVLEKYRNSNLLRVANKLYVQEGKQLKPA--------YQSAIKEQYHSEAESINFALNDAAAQA 133
            :.::..: |.:.:...:.::||...:|...        ::|.:|:...||.|...|.:||
Human   103 KELMGPW-NKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIIND----- 161

  Fly   134 INAWVNAKTQGKITELVSADSFSDNTRLVLLNALHFKGSWAHKFSEERTEEDIFWVGEEEQVKIN 198
               ||...|:|.|:.|:...:....|||||:|||:|.|.|...|.:..|...:|...:...|.:.
Human   162 ---WVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVP 223

  Fly   199 YMNQKAKFNY-------GFFEDLGCTALEMPYQDSDLSMFVLLPQERTGIYALAEKLKTVNLVDL 256
            .|.|..||||       |.:.|:    ||:||....||||:..|.|           |.|.|..|
Human   224 MMAQTNKFNYTEFTTPDGHYYDI----LELPYHGDTLSMFIAAPYE-----------KEVPLSAL 273

  Fly   257 ADKLTVEEV-HVK-----------FPKFKVDYSLELAEKLKQLGITKMFTD-QAEFSNLLESPEG 308
            .:.|:.:.: |.|           .|||.::..::|.:.|:.||:|.||.. ||:|::|.:. |.
Human   274 TNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQ-EP 337

  Fly   309 VFVSKVLHKATIEVNEEGTEAAAATGMIMMTRMMTFPLQFQADRPFLYVI-WNKKNIL------F 366
            :.|::.|.|..|||||.||.|:::|.:|:..||.  |.:...|||||:|: .|....|      .
Human   338 LHVAQALQKVKIEVNESGTVASSSTAVIVSARMA--PEEIIMDRPFLFVVRHNPTGPLQDGTTGL 400

  Fly   367 AGAFV 371
            .||||
Human   401 TGAFV 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn55B	NP_524953.1	SERPIN	13..370	CDD:238101	115/392 (29%)
SERPINE1	NP_001373389.1	serpinE1_PAI-1	29..393	CDD:381007	113/381 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.020