Protein Alignment Spn55B and SERPINC1

DIOPT Version :10

• Sequence 1: NP_524953.1
• Gene: Spn55B / 49803
• FlyBaseID: FBgn0028983
• Length: 374
• Species: Drosophila melanogaster
• Sequence 2: NP_001373231.1
• Gene: SERPINC1 / 462
• HGNCID: 775
• Length: 505
• Species: Homo sapiens
• Alignment Length: 419
• Identity: 109/419 - (26%)
• Similarity: 204/419 - (48%)
• Gaps: 60/419 - (14%)

  Fly     7 EFARGGARFTSELFQ-LLSAGGLKENVVFSPFSIQTCIALAFAGSQGETADEIAKALHFVSNFPP 70
            |.::..:||.:..:| |..:....:|:..||.||.|..|:...|:..:|..::.:...| .....
Human    82 ELSKANSRFATTFYQHLADSKNDNDNIFLSPLSISTAFAMTKLGACNDTLQQLMEVFKF-DTISE 145

  Fly    71 EVAQTFQFVLEK-----YRNSN---LLRVANKLYVQEGKQLKPAYQSAIKEQYHSEAESINFALN 127
            :.:....|...|     ||.:|   .|..||:|:..:.......||...:..|.::.:.::|..|
Human   146 KTSDQIHFFFAKLNCRLYRKANKSSKLVSANRLFGDKSLTFNETYQDISELVYGAKLQPLDFKEN 210

  Fly   128 -DAAAQAINAWVNAKTQGKITELVSADSFSDNTRLVLLNALHFK--------------------- 170
             :.:..|||.||:.||:|:||:::.:::.::.|.|||:|.::||
Human   211 AEQSRAAINKWVSNKTEGRITDVIPSEAINELTVLVLVNTIYFKVLRMALERPQGLPLALQLTPF 275

  Fly   171 --------------------GSWAHKFSEERTEEDIFWVGEEEQVKINYMNQKAKFNYGFFEDLG 215
                                |.|..|||.|.|.:::|:..:.|....:.|.|:.||.|....: |
Human   276 FFKWRDRSPERANGLPKATQGLWKSKFSPENTRKELFYKADGESCSASMMYQEGKFRYRRVAE-G 339

  Fly   216 CTALEMPYQDSDLSMFVLLPQERTGIYALAEKLKTVNLVDLADKLTVEEVHVKFPKFKVDYSLEL 280
            ...||:|::..|::|.::||:....:..:.::|....|.:..|:|....:.|..|:|:::....|
Human   340 TQVLELPFKGDDITMVLILPKPEKSLAKVEKELTPEVLQEWLDELEEMMLVVHMPRFRIEDGFSL 404

  Fly   281 AEKLKQLGITKMFT-DQAEFSNLL-ESPEGVFVSKVLHKATIEVNEEGTEAAAATGMIMMTRMMT 343
            .|:|:.:|:..:|: ::::...:: |..:.::||...|||.:||||||:||||:|.:::..|.:.
Human   405 KEQLQDMGLVDLFSPEKSKLPGIVAEGRDDLYVSDAFHKAFLEVNEEGSEAAASTAVVIAGRSLN 469

  Fly   344 FP--LQFQADRPFLYVIWN--KKNILFAG 368
             |  :.|:|:||||..|..  ...|:|.|
Human   470 -PNRVTFKANRPFLVFIREVPLNTIIFMG 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spn55B	NP_524953.1	serpin42Da-like	15..368	CDD:381065	106/409 (26%)
SERPINC1	NP_001373231.1	serpinC1_AT3	70..504	CDD:381002	109/419 (26%)