DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spn55B and Serpina3n

DIOPT Version :9

Sequence 1:	NP_524953.1	Gene:	Spn55B / 49803	FlyBaseID:	FBgn0028983	Length:	374	Species:	Drosophila melanogaster
Sequence 2:	NP_113719.3	Gene:	Serpina3n / 24795	RGDID:	3747	Length:	418	Species:	Rattus norvegicus

Alignment Length:	367	Identity:	115/367 - (31%)
Similarity:	197/367 - (53%)	Gaps:	23/367 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 NLEFARGGARFTSELFQLLSAGGLKENVVFSPFSIQTCIALAFAGSQGETADEIAKALHFVSNFP 69
            :|..|.....|...|::.|:.....:||||||.||...:|:...|::|.:.:||.:.|.|.....
  Rat    44 SLTLASINTDFAFSLYKKLALRNPDKNVVFSPLSISAALAVVSLGAKGNSMEEILEGLKFNLTET 108

  Fly    70 P--EVAQTFQFVLEKY---RNSNLLRVANKLYVQEGKQLKPAYQSAIKEQYHSEAESINFALNDA 129
            |  |:.:.|..:|::.   |:...:...|.|::::..|:...:|...|..|.:||.:.:|..:..
  Rat   109 PETEIHRGFGHLLQRLSQPRDEIQISTGNALFIEKRLQVLAEFQEKAKALYQAEAFTADFQQSRE 173

  Fly   130 AAQAINAWVNAKTQGKITELVSADSFSDNTRLVLLNALHFKGSWAHKFSEERTEEDIFWVGEEEQ 194
            |.:.||.:|:.:|||||..|::  :.:..|.:||:|.::|||.|...|....|.:..|:.|:...
  Rat   174 AKKLINDYVSKQTQGKIQGLIT--NLAKKTSMVLVNYIYFKGKWKVPFDPRDTFQSEFYSGKRRP 236

  Fly   195 VKINYMN-QKAKFNYGFFEDLGCTALEMPYQDSDLSMFVLLPQERTGIYALAEKLKTVNLVDLAD 258
            ||:..|. :.....|...|:|.||.:|:.|..:..::|:|..|.:  :..:...|:...|....|
  Rat   237 VKVPMMKLEDLTTPYVRDEELNCTVVELKYTGNASALFILPDQGK--MQQVEASLQPETLRRWKD 299

  Fly   259 KL---TVEEVHVKFPKFKV--DYSLELAEKLKQLGITKMFTDQAEFSNLLESPEGVFVSKVLHKA 318
            .|   .::|:::  |||.:  ||:||  :.|.:|||.::|:.||:.|. :...:.:.||:|:|||
  Rat   300 SLRPSMIDELYL--PKFSISADYNLE--DVLPELGIKEVFSTQADLSG-ITGDKDLMVSQVVHKA 359

  Fly   319 TIEVNEEGTEAAAATGM--IMMTRMMTFPLQFQADRPFLYVI 358
            .::|.|.|||||||||:  :.|:..:. ||....|||||.:|
  Rat   360 VLDVAETGTEAAAATGVKFVPMSAKLD-PLIIAFDRPFLMII 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn55B	NP_524953.1	SERPIN	13..370	CDD:238101	113/359 (31%)
Serpina3n	NP_113719.3	serpinA3_A1AC	37..418	CDD:381019	115/367 (31%)
Serpina3n	NP_113719.3	RCL	367..394		12/27 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010