DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn55B and Serpinf1

DIOPT Version :9

Sequence 1:	NP_524953.1	Gene:	Spn55B / 49803	FlyBaseID:	FBgn0028983	Length:	374	Species:	Drosophila melanogaster
Sequence 2:	NP_035470.3	Gene:	Serpinf1 / 20317	MGIID:	108080	Length:	417	Species:	Mus musculus

Alignment Length:	389	Identity:	102/389 - (26%)
Similarity:	188/389 - (48%)	Gaps:	58/389 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 EFARGGARFTSELFQLLSAGGLKENVVFSPFSIQTCIALAFAGSQGETADEIAKALHF--VSNFP 69
            :.|...:.|..:|::|.|:.....||:.||.|:.|.::....|::..|...|.:||::  ::|
Mouse    52 KLAAAVSNFGYDLYRLRSSASPTGNVLLSPLSVATALSALSLGAEHRTESVIHRALYYDLITN-- 114

  Fly    70 PEVAQTFQFVLEKY----RNSNLLRVANKLYVQEGKQLKPAYQSAIKEQYHSEAESI--NFALND 128
            |::..|::.:|...    :|   |:.|:::..:...::|.::.:.:::.|.:....:  |..::
Mouse   115 PDIHSTYKELLASVTAPEKN---LKSASRIVFERKLRVKSSFVAPLEKSYGTRPRILTGNPRVD- 175

  Fly   129 AAAQAINAWVNAKTQGKIT----ELVSADSFSDNTRLVLLNALHFKGSWAHKFSEERTEEDIFWV 189
              .|.||.||.|:.:|||.    |:.||.|      ::||...:|||.|..||...:|....|.:
Mouse   176 --LQEINNWVQAQMKGKIARSTREMPSALS------ILLLGVAYFKGQWVTKFDSRKTTLQDFHL 232

  Fly   190 GEEEQVKINYMNQ-KAKFNYGFFEDLGCTALEMPYQDSDLSMFVLLPQERTGIYALAEKLKTVNL 253
            .|:..|::..|:. ||...||...||.|...::|...| :|:...||           ...|.||
Mouse   233 DEDRTVRVPMMSDPKAILRYGLDSDLNCKIAQLPLTGS-MSIIFFLP-----------LTVTQNL 285

  Fly   254 VDLADKLTVEEVH------------VKFPKFKVDYSLELAEKLKQLGITKMFTDQAEFSNLLESP 306
            ..:.:.||.|.:|            :..||.|:.:..||.:.|:.:.:..:| :..:||.:...|
Mouse   286 TMIEESLTSEFIHDIDRELKTIQAVLTVPKLKLSFEGELTKSLQDMKLQSLF-ESPDFSKITGKP 349

  Fly   307 EGVFVSKVLHKATIEVNEEGTEAAAATGMIMMTRMMTFPLQFQADRPFLYVIWNKKN--ILFAG 368
              |.:::|.|:|..|.||||..::.:.|  :....:||||.:..::|||:|:.:...  :||.|
Mouse   350 --VKLTQVEHRAAFEWNEEGAGSSPSPG--LQPVRLTFPLDYHLNQPFLFVLRDTDTGALLFIG 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn55B	NP_524953.1	SERPIN	13..370	CDD:238101	101/383 (26%)
Serpinf1	NP_035470.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	17..41
Serpinf1	NP_035470.3	PEDF	39..414	CDD:239007	102/389 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010