DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn55B and Serping1

DIOPT Version :9

Sequence 1:	NP_524953.1	Gene:	Spn55B / 49803	FlyBaseID:	FBgn0028983	Length:	374	Species:	Drosophila melanogaster
Sequence 2:	NP_033906.2	Gene:	Serping1 / 12258	MGIID:	894696	Length:	504	Species:	Mus musculus

Alignment Length:	369	Identity:	93/369 - (25%)
Similarity:	167/369 - (45%)	Gaps:	52/369 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 FTSELFQLLSAGGL-KENVVFSPFSIQTCIALAFAGSQGETADEIAKALHFVSNFPPEVAQTFQF 78
            |:.:|:...||..: |.|:.||||||.:.:.....|:    .|.....|..:.::|.:.|...|
Mouse   154 FSVKLYHAFSATKMAKTNMAFSPFSIASLLTQVLLGA----GDSTKSNLESILSYPKDFACVHQ- 213

  Fly    79 VLEKYRNSNLLRVANKLYVQEGKQLKPAYQSAIKEQYHSEAESINFALNDAAA--QAINAWVNAK 141
            .|:.:.:..:..| ::::......::..|.:|.:..|.|....:.   .|:||  :.||.||...
Mouse   214 ALKGFSSKGVTSV-SQIFHSPDLAIRDTYVNASQSLYGSSPRVLG---PDSAANLELINTWVAEN 274

  Fly   142 TQGKITELVSADSFSDNTRLVLLNALHFKGSWAHKFSEERTEEDIFWVGEEEQVKINYMNQKAKF 206
            |..||.:|:  ||...:|.||||||::....|...|..::.....|:  :...:|:..|: ..|:
Mouse   275 TNHKIRKLL--DSLPSDTCLVLLNAVYLSAKWKITFEPKKMMAPFFY--KNSMIKVPMMS-SVKY 334

  Fly   207 NYGFFEDLGCTA----LEMPYQDSDLSMFVLLPQER----------TGIYALAEKLKTVNLVDLA 257
            ....|:|....|    |::.:..|.:.:..:.|:.:          |...|:.:||:....:
Mouse   335 PVAQFDDHTLKAKVGQLQLSHNLSFVIVVPVFPKHQLKDVEKALNPTVFKAIMKKLELSKFL--- 396

  Fly   258 DKLTVEEVHVKFPKFKVDYS---LELAEKLKQLGITKMFTDQAEFSNLLESPEGVFVSKVLHKAT 319
                  ..::..|..||..|   |.:.|||:...    ||.......|.|.|: :.||.:.|:..
Mouse   397 ------PTYLTMPHIKVKSSQDMLSVMEKLEFFD----FTYDLNLCGLTEDPD-LQVSAMKHETV 450

  Fly   320 IEVNEEGTEAAAATGMIMMTRMMTFPLQFQADRPFLYVIWNKKN 363
            :|:.|.|.|||||:. |...|  :.|: |:..||||:::|::::
Mouse   451 LELTESGVEAAAASA-ISFGR--SLPI-FEVQRPFLFLLWDQQH 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn55B	NP_524953.1	SERPIN	13..370	CDD:238101	93/369 (25%)
Serping1	NP_033906.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..67
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	85..141
		serpinG1_C1-INH	141..500	CDD:381006	93/369 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010