DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spn55B and Serpinb5

DIOPT Version :9

Sequence 1:	NP_524953.1	Gene:	Spn55B / 49803	FlyBaseID:	FBgn0028983	Length:	374	Species:	Drosophila melanogaster
Sequence 2:	NP_476449.2	Gene:	Serpinb5 / 116589	RGDID:	69342	Length:	375	Species:	Rattus norvegicus

Alignment Length:	369	Identity:	115/369 - (31%)
Similarity:	204/369 - (55%)	Gaps:	20/369 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 FTSELFQLLSAGGLKENVVFSPFSIQTCIALAFAGSQGETADEIAKALHF--VSNFPPEVAQTFQ 77
            |..|||:.|.......|::|||..:.|.::||..|::|:||:||.:.|||  |.:.|... ||..
  Rat    11 FAVELFKQLCEKEPAGNILFSPICLSTSLSLAQVGAKGDTANEIGQVLHFENVKDVPFGF-QTIT 74

  Fly    78 FVLEKYRNSNLLRVANKLYVQEGKQLKPAYQSAIKEQYHSEAESINF--ALNDAAAQAINAWVNA 140
            ..:.|..:...|::..:||:.:...|...:.|:.|..|.:|.|:::|  .|.:...| ||:.:..
  Rat    75 SDVNKLSSFYSLKLIKRLYIDKSLNLSTEFISSTKRPYANELETVDFKDKLEETKGQ-INSSIKE 138

  Fly   141 KTQGKITELVSADSFSDNTRLVLLNALHFKGSWAHKFSEERTEEDIFWVGEEEQVKINYMNQKAK 205
            .|.|...:::..:|.||.|:::::||.:|.|.|..||.|..|:|..|.:.:.:...:..||.:|.
  Rat   139 LTDGHFEDILPENSISDQTKILVVNAAYFVGKWMKKFPESETKECPFRINKTDTKPVQMMNLEAT 203

  Fly   206 FNYGFFEDLGCTALEMPYQDSDLSMFVLLPQ----ERTGIYALAEKLKTVNLVDLADKLTVEEVH 266
            |..|..:|:.|..:|:|:|:..|||.::||:    |.||:..:.::|....|:...:..|:....
  Rat   204 FCLGNIDDINCKIIELPFQNKHLSMLIVLPKDVEDESTGLEKIEKQLNPETLLQWTNPSTMANAK 268

  Fly   267 VK--FPKFKVDYSLELAEKLKQLGITKMFTDQ-AEFSNLLESPEGVFVSKVLHKATIEVNEEGTE 328
            ||  .|||||:..::....|:.||:..:|.:. ::||.:.|: :||.||.|:|:..:|:.|:|.:
  Rat   269 VKLSLPKFKVEKMIDPKASLESLGLKSLFNESTSDFSGMSET-KGVSVSNVIHRVCLEITEDGGD 332

  Fly   329 AAAATGMIMMTRMMTFPLQFQADRPFLYVIWNKK--NILFAGAF 370
            :....|    :|::....:|:||.|||:::.:.|  ||:|.|.|
  Rat   333 SIEVPG----SRILQHKDEFKADHPFLFIVRHNKTRNIVFLGKF 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn55B	NP_524953.1	SERPIN	13..370	CDD:238101	114/367 (31%)
Serpinb5	NP_476449.2	serpinB5_maspin	1..375	CDD:381013	115/369 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	228	1.000	Domainoid score	I2400
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	229	1.000	Inparanoid score	I3374
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm12319
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.980