DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PpD6 and PPP3CB

DIOPT Version :9

Sequence 1:	NP_524947.1	Gene:	PpD6 / 49780	FlyBaseID:	FBgn0005779	Length:	336	Species:	Drosophila melanogaster
Sequence 2:	NP_001135825.1	Gene:	PPP3CB / 5532	HGNCID:	9315	Length:	525	Species:	Homo sapiens

Alignment Length:	314	Identity:	112/314 - (35%)
Similarity:	177/314 - (56%)	Gaps:	27/314 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 QLSNSEANADYRLPGALNLNDLLNKLMSFRRSKMQRLPLLESEVNL-LCTLARELFLDEPMLLNV 77
            :|::.|.   :.|.|...::.|.|.|:...|        ::.|:.| :......:...|..::.|
Human    37 RLTSEEV---FDLDGIPRVDVLKNHLVKEGR--------VDEEIALRIINEGAAILRREKTMIEV 90

  Fly    78 PAPIRVVGDIHGQFYDLLKILDQCGYPPQTRYLFLGDYVDRGKNSVETITLLLALRVKFPKHIYL 142
            .|||.|.|||||||:||:|:.:..|.|..|||||||||||||..|:|.:..|..|::.:|..::|
Human    91 EAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFL 155

  Fly   143 LRGNHESQSVNRVYGFFDECKRRYTVKLWKTFVDCYNCMPVAAIISHRIFCCHGGLSPQLKELSN 207
            ||||||.:.:...:.|..|||.:|:.::::..::.::.:|:||:::.:..|.||||||::..|.:
Human   156 LRGNHECRHLTEYFTFKQECKIKYSERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDD 220

  Fly   208 IESIARPTEVPETGLLCDLLWSDPDRYGFGWTSSD--------RGVSYLYGRDVLEKFLQKNDFD 264
            |..:.|..|.|..|.:||||||||.. .||...|.        ||.||.|....:.:|||.|:..
Human   221 IRRLDRFKEPPAFGPMCDLLWSDPSE-DFGNEKSQEHFSHNTVRGCSYFYNYPAVCEFLQNNNLL 284

  Fly   265 LVCRAHQVVEDGYEFFAKRQ------LVTVFSAPNYCGLYDNAGASMGVDKDLV 312
            .:.|||:..:.||..:.|.|      |:|:||||||..:|:|..|.:..:.:::
Human   285 SIIRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVM 338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PpD6	NP_524947.1	MPP_superfamily	51..317	CDD:301300	104/277 (38%)
PpD6	NP_524947.1	PP2Ac	54..315	CDD:197547	104/274 (38%)
PPP3CB	NP_001135825.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		MPP_PP2B	50..354	CDD:277361	108/298 (36%)
		Catalytic. /evidence=ECO:0000305	65..356		104/275 (38%)
		SAPNY motif. /evidence=ECO:0000250\|UniProtKB:Q08209	316..320		3/3 (100%)
		Calcineurin B binding. /evidence=ECO:0000269\|PubMed:26794871	357..379
		Calmodulin-binding. /evidence=ECO:0000269\|PubMed:26794871	402..416
		Autoinhibitory segment. /evidence=ECO:0000269\|PubMed:26794871	417..424
		Autoinhibitory domain. /evidence=ECO:0000269\|PubMed:26794871	475..497
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0639
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53795
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820