DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PpD6 and PPP3CA

DIOPT Version :9

Sequence 1:	NP_524947.1	Gene:	PpD6 / 49780	FlyBaseID:	FBgn0005779	Length:	336	Species:	Drosophila melanogaster
Sequence 2:	NP_000935.1	Gene:	PPP3CA / 5530	HGNCID:	9314	Length:	521	Species:	Homo sapiens

Alignment Length:	274	Identity:	109/274 - (39%)
Similarity:	168/274 - (61%)	Gaps:	14/274 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 LESEVNL-LCTLARELFLDEPMLLNVPAPIRVVGDIHGQFYDLLKILDQCGYPPQTRYLFLGDYV 116
            ||..|.| :.|....:...|..||::.||:.|.|||||||:||:|:.:..|.|..||||||||||
Human    56 LEESVALRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYV 120

  Fly   117 DRGKNSVETITLLLALRVKFPKHIYLLRGNHESQSVNRVYGFFDECKRRYTVKLWKTFVDCYNCM 181
            |||..|:|.:..|.||::.:||.::|||||||.:.:...:.|..|||.:|:.:::...:|.::|:
Human   121 DRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAFDCL 185

  Fly   182 PVAAIISHRIFCCHGGLSPQLKELSNIESIARPTEVPETGLLCDLLWSDP-DRYGFGWT------ 239
            |:||:::.:..|.||||||::..|.:|..:.|..|.|..|.:||:||||| :.:|...|
Human   186 PLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPLEDFGNEKTQEHFTH 250

  Fly   240 SSDRGVSYLYGRDVLEKFLQKNDFDLVCRAHQVVEDGYEFFAKRQ------LVTVFSAPNYCGLY 298
            ::.||.||.|....:.:|||.|:...:.|||:..:.||..:.|.|      |:|:||||||..:|
Human   251 NTVRGCSYFYSYPAVCEFLQHNNLLSILRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVY 315

  Fly   299 DNAGASMGVDKDLV 312
            :|..|.:..:.:::
Human   316 NNKAAVLKYENNVM 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PpD6	NP_524947.1	MPP_superfamily	51..317	CDD:301300	109/274 (40%)
PpD6	NP_524947.1	PP2Ac	54..315	CDD:197547	108/273 (40%)
PPP3CA	NP_000935.1	MPP_PP2B	41..345	CDD:277361	109/274 (40%)
		Catalytic. /evidence=ECO:0000305	56..340		109/274 (40%)
		SAPNY motif. /evidence=ECO:0000305\|PubMed:26248042	307..311		3/3 (100%)
		Interaction with PxIxIF motif in substrate. /evidence=ECO:0000269\|PubMed:17498738, ECO:0000269\|PubMed:17502104, ECO:0000269\|PubMed:22343722, ECO:0000269\|PubMed:23468591, ECO:0000269\|PubMed:26248042	327..336		0/3 (0%)
		Calcineurin B binding. /evidence=ECO:0000269\|PubMed:12218175, ECO:0000269\|PubMed:12357034, ECO:0000269\|PubMed:17498738, ECO:0000269\|PubMed:23468591, ECO:0000269\|PubMed:27974827, ECO:0000269\|PubMed:8524402	341..369
		Calmodulin-binding. /evidence=ECO:0000269\|PubMed:18384083, ECO:0000269\|PubMed:19404396, ECO:0000269\|PubMed:25144868, ECO:0000269\|Ref.31	392..406
		Autoinhibitory segment. /evidence=ECO:0000250\|UniProtKB:P16298	407..414
		Autoinhibitory domain. /evidence=ECO:0000269\|PubMed:8524402	465..487
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	475..521
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0639
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53795
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820