DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PpD6 and PPP1CB

DIOPT Version :9

Sequence 1:	NP_524947.1	Gene:	PpD6 / 49780	FlyBaseID:	FBgn0005779	Length:	336	Species:	Drosophila melanogaster
Sequence 2:	NP_002700.1	Gene:	PPP1CB / 5500	HGNCID:	9282	Length:	327	Species:	Homo sapiens

Alignment Length:	291	Identity:	174/291 - (59%)
Similarity:	231/291 - (79%)	Gaps:	1/291 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 GALNLNDLLNKLMSFRRSKMQRL-PLLESEVNLLCTLARELFLDEPMLLNVPAPIRVVGDIHGQF 91
            |.||::.|:.:|:..|..:..:: .:.|:||..||..:||:||.:|:||.:.||:::.||||||:
Human     4 GELNVDSLITRLLEVRGCRPGKIVQMTEAEVRGLCIKSREIFLSQPILLELEAPLKICGDIHGQY 68

  Fly    92 YDLLKILDQCGYPPQTRYLFLGDYVDRGKNSVETITLLLALRVKFPKHIYLLRGNHESQSVNRVY 156
            .|||::.:..|:||:..||||||||||||.|:|||.||||.::|:|::.:|||||||..|:||:|
Human    69 TDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIY 133

  Fly   157 GFFDECKRRYTVKLWKTFVDCYNCMPVAAIISHRIFCCHGGLSPQLKELSNIESIARPTEVPETG 221
            ||:||||||:.:||||||.||:||:|:|||:..:||||||||||.|:.:..|..|.|||:||:||
Human   134 GFYDECKRRFNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDTG 198

  Fly   222 LLCDLLWSDPDRYGFGWTSSDRGVSYLYGRDVLEKFLQKNDFDLVCRAHQVVEDGYEFFAKRQLV 286
            |||||||||||:...||..:|||||:.:|.||:.|||.::|.||:||||||||||||||||||||
Human   199 LLCDLLWSDPDKDVQGWGENDRGVSFTFGADVVSKFLNRHDLDLICRAHQVVEDGYEFFAKRQLV 263

  Fly   287 TVFSAPNYCGLYDNAGASMGVDKDLVISFDI 317
            |:||||||||.:||||..|.||:.|:.||.|
Human   264 TLFSAPNYCGEFDNAGGMMSVDETLMCSFQI 294

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PpD6	NP_524947.1	MPP_superfamily	51..317	CDD:301300	167/265 (63%)
PpD6	NP_524947.1	PP2Ac	54..315	CDD:197547	165/260 (63%)
PPP1CB	NP_002700.1	MPP_PP1_PPKL	7..297	CDD:277359	172/288 (60%)
PPP1CB	NP_002700.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	305..327
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158260
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0639
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53795
OrthoDB	1	1.010	-	-		D327461at33208
OrthoFinder	1	1.000	-	-		FOG0000018
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100222
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.660