DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PpD6 and Ppp3cc

DIOPT Version :9

Sequence 1:	NP_524947.1	Gene:	PpD6 / 49780	FlyBaseID:	FBgn0005779	Length:	336	Species:	Drosophila melanogaster
Sequence 2:	NP_001291920.1	Gene:	Ppp3cc / 19057	MGIID:	107162	Length:	522	Species:	Mus musculus

Alignment Length:	294	Identity:	110/294 - (37%)
Similarity:	171/294 - (58%)	Gaps:	23/294 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 DLL-NKLMSFRRSKMQRLPLLESEVNL-LCTLARELFLDEPMLLNVPAPIRVVGDIHGQFYDLLK 96
            ||| |.|:...|        :|.||.| :......:...|..::.|.|||.|.||:||||:||:|
Mouse    40 DLLKNHLVKEGR--------VEEEVALKIINDGAAILKQEKTMIEVEAPITVCGDVHGQFFDLMK 96

  Fly    97 ILDQCGYPPQTRYLFLGDYVDRGKNSVETITLLLALRVKFPKHIYLLRGNHESQSVNRVYGFFDE 161
            :.:..|.|..|||||||||||||..|:|.:..|.:|::..||.::|||||||.:.:...:.|..|
Mouse    97 LFEVGGSPSNTRYLFLGDYVDRGYFSIECVLYLWSLKINHPKTLFLLRGNHECRHLTEYFTFKQE 161

  Fly   162 CKRRYTVKLWKTFVDCYNCMPVAAIISHRIFCCHGGLSPQLKELSNIESIARPTEVPETGLLCDL 226
            |:.:|:..::...:..::|:|:||:::.:..|.|||:||::..|.:|..:.|.:|.|..|.:|||
Mouse   162 CRIKYSEMVYDACMHTFDCLPLAALLNQQFLCVHGGMSPEITCLEDIRKLDRFSEPPAFGPVCDL 226

  Fly   227 LWSDP-DRYGFGWT------SSDRGVSYLYGRDVLEKFLQKNDFDLVCRAHQVVEDGYEFFAKRQ 284
            ||||| :.||...|      ::.||.||.:....:.:|||.|....:.|||:..:.||..:.|.|
Mouse   227 LWSDPLEDYGSEKTLEHYTHNTVRGCSYFFSYPAVCEFLQNNSLLSIIRAHEAQDAGYRMYRKNQ 291

  Fly   285 ------LVTVFSAPNYCGLYDNAGASMGVDKDLV 312
                  |:|:||||||..:|:|..|.:..:.:::
Mouse   292 ATGFPSLITIFSAPNYLDVYNNKAAVLKYENNVM 325

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PpD6	NP_524947.1	MPP_superfamily	51..317	CDD:301300	104/276 (38%)
PpD6	NP_524947.1	PP2Ac	54..315	CDD:197547	104/273 (38%)
Ppp3cc	NP_001291920.1	MPP_PP2B	37..341	CDD:277361	110/294 (37%)
		Catalytic. /evidence=ECO:0000305	52..343		104/274 (38%)
		PP2Ac	54..325	CDD:197547	103/270 (38%)
		SAPNY motif. /evidence=ECO:0000250\|UniProtKB:Q08209	303..307		3/3 (100%)
		Calcineurin B binding. /evidence=ECO:0000250\|UniProtKB:P16298	344..366
		Calmodulin-binding. /evidence=ECO:0000250\|UniProtKB:P16298	394..408
		Autoinhibitory segment. /evidence=ECO:0000250\|UniProtKB:P16298	409..416
		Autoinhibitory domain. /evidence=ECO:0000250\|UniProtKB:P16298	467..489
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	481..522
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0639
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53795
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910