DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PpD3 and SIT4

DIOPT Version :9

Sequence 1:	NP_001262433.1	Gene:	PpD3 / 49779	FlyBaseID:	FBgn0005777	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_010236.1	Gene:	SIT4 / 851513	SGDID:	S000002205	Length:	311	Species:	Saccharomyces cerevisiae

Alignment Length:	307	Identity:	117/307 - (38%)
Similarity:	163/307 - (53%)	Gaps:	22/307 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   199 KGPQLEDGKVTLKFMKELMEHYKAQKRLHRKFAYKILCEIDTYMRAQPSLVDITVPDEEKFTICG 263
            :||  ::...|:|..:.|.|:...|           |||:...:..:.|.:.   |.:...|:||
Yeast     4 RGP--DEWLETIKKCQALTENEMKQ-----------LCEMVKELLMEESNIQ---PVQTPVTVCG 52

  Fly   264 DIHGQFYDLMNIFE-INGLPSEKNPYLFNGDFVDRGSFSVECIFTLFGFKLLYPNHFFLARGNHE 327
            ||||||:||:.:|. ..|.|.:.| |:|.||:||||.:|:|....|...|:.||....|.|||||
Yeast    53 DIHGQFHDLLELFRTAGGFPDDIN-YIFLGDYVDRGYYSLETFTLLMCLKVKYPAKITLVRGNHE 116

  Fly   328 SINMNQMYGFTGEVTAKYTSAMA-DIFTQVFNWLPLCHCINQKILVMHGGLFSTEDVTLDHIRRI 391
            |..:.|:|||..|...||.|... ....|||::|.|...|:.|||.:|||| |.|...||.||.:
Yeast   117 SRQITQVYGFYEECLNKYGSTTVWKYCCQVFDFLTLAAIIDGKILCVHGGL-SPEIRMLDQIRVL 180

  Fly   392 ERNCQPPEEGLMCELLWSDPQQWMGLGQSKRGVGIQFGPDVTEKFCKDNNLDYIIRSHEVKDMGY 456
            .|..:.|.||...:||||||........|.||.|..||..|..:|...|.|:.|.|:|::...|:
Yeast   181 SRAQEVPHEGGFSDLLWSDPDNVEAWQVSPRGAGWLFGSKVAREFNHVNGLNLIARAHQLVMEGF 245

  Fly   457 EVAHNGK-CITVFSAPNYCDTMGNMGAFITITGNNLKPNYKSFEAVP 502
            :.....| .:||:||||||...||:.:.:.: ..:|:|.:|.|.|||
Yeast   246 KYHFPEKDVVTVWSAPNYCYRCGNVASVMKV-DEDLEPTFKIFSAVP 291

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PpD3	NP_001262433.1	TPR_11	49..114	CDD:290150
		TPR_1	49..81	CDD:278916
		TPR repeat	49..77	CDD:276809
		TPR repeat	82..112	CDD:276809
		MPP_PP5_C	198..513	CDD:277362	117/307 (38%)
		PP2Ac	226..502	CDD:197547	108/278 (39%)
SIT4	NP_010236.1	MPP_PP2A_PP4_PP6	7..291	CDD:277360	113/300 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0639
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900