DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PpD3 and CNA1

DIOPT Version :9

Sequence 1:	NP_001262433.1	Gene:	PpD3 / 49779	FlyBaseID:	FBgn0005777	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_013537.1	Gene:	CNA1 / 851153	SGDID:	S000004425	Length:	553	Species:	Saccharomyces cerevisiae

Alignment Length:	387	Identity:	136/387 - (35%)
Similarity:	193/387 - (49%)	Gaps:	53/387 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 RPNDK----DAKLKFT----ECNKIVKMRAFERAIAVDKPEKTLSEMYSDMENITIEDDYKGPQL 203
            :|||.    |.|...|    |..|::..:  :|.|| ..|..| .::.||.|            :
Yeast    14 KPNDSYIKVDRKKDLTKYELENGKVISTK--DRPIA-SVPAIT-GKIPSDEE------------V 62

  Fly   204 EDGKVTLKFMKELMEHYKAQKRLHRKFAYKILCEIDTYMRAQPSLVDITVPDEEKFTICGDIHGQ 268
            .|.|..|.....|.||:..:.||.::.|.|||......:..:|:|:.:..|    .|||||||||
Yeast    63 FDSKTGLPNHSFLREHFFHEGRLSKEQAIKILNMSTVALSKEPNLLKLKAP----ITICGDIHGQ 123

  Fly   269 FYDLMNIFEINGLPSEKNPYLFNGDFVDRGSFSVECIFTLFGFKLLYPNHFFLARGNHESINMNQ 333
            :|||:.:||:.|.|:|.: |||.||:||||:||.||:..|:..||.....|::.|||||..::..
Yeast   124 YYDLLKLFEVGGDPAEID-YLFLGDYVDRGAFSFECLIYLYSLKLNNLGRFWMLRGNHECKHLTS 187

  Fly   334 MYGFTGEVTAKYTSAMADIFTQVFNWLPLCHCINQKILVMHGGLFSTEDVTLDHIRRIERNCQPP 398
            .:.|..|:..||...:.|...:.||.|||...:|.:...:|||: |.|..:::.:.:|.|..:.|
Yeast   188 YFTFKNEMLHKYDMEVYDACCRSFNVLPLAALMNGQYFCVHGGI-SPELKSVEDVNKINRFREIP 251

  Fly   399 EEGLMCELLWSDP-------QQWMGLGQSK--------RGVGIQFGPDVTEKFCKDNNLDYIIRS 448
            ..||||:|||:||       :......||:        ||....|....:.||.|.|.|..|||:
Yeast   252 SRGLMCDLLWADPVENYDDARDGSEFDQSEDEFVPNSLRGCSFAFTFKASCKFLKANGLLSIIRA 316

  Fly   449 HEVKDMGYEVAHNGK------CITVFSAPNYCDTMGNMGAFITITGNNLKPNYKSFEAVPHP 504
            ||.:|.||.:..|.|      .||:||||||.||..|..|.:....|.:  |.:.|...|||
Yeast   317 HEAQDAGYRMYKNNKVTGFPSLITMFSAPNYLDTYHNKAAVLKYEENVM--NIRQFHMSPHP 376

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PpD3	NP_001262433.1	TPR_11	49..114	CDD:290150
		TPR_1	49..81	CDD:278916
		TPR repeat	49..77	CDD:276809
		TPR repeat	82..112	CDD:276809
		MPP_PP5_C	198..513	CDD:277362	120/328 (37%)
		PP2Ac	226..502	CDD:197547	110/296 (37%)
CNA1	NP_013537.1	MPP_PP2B	70..381	CDD:277361	117/315 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0639
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900