DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PpD3 and PPP6C

DIOPT Version :9

Sequence 1:	NP_001262433.1	Gene:	PpD3 / 49779	FlyBaseID:	FBgn0005777	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001116827.1	Gene:	PPP6C / 5537	HGNCID:	9323	Length:	342	Species:	Homo sapiens

Alignment Length:	295	Identity:	116/295 - (39%)
Similarity:	165/295 - (55%)	Gaps:	27/295 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   210 LKFMKELMEHYKAQKRLHRKFAYKILCEIDTYMRAQPSLVDITVPDEEKFTICGDIHGQFYDLMN 274
            |:|:||.:..|              :|::   :..:.::..::.|    .|:|||||||||||..
Human    57 LRFLKERLCDY--------------VCDL---LLEESNVQPVSTP----VTVCGDIHGQFYDLCE 100

  Fly   275 IFEINGLPSEKNPYLFNGDFVDRGSFSVECIFTLFGFKLLYPNHFFLARGNHESINMNQMYGFTG 339
            :|...|...:.| |:|.|||||||.:|:|....|...|..:|:...|.||||||..:.|:|||..
Human   101 LFRTGGQVPDTN-YIFMGDFVDRGYYSLETFTYLLALKAKWPDRITLLRGNHESRQITQVYGFYD 164

  Fly   340 EVTAKYTSAMADIF-TQVFNWLPLCHCINQKILVMHGGLFSTEDVTLDHIRRIERNCQPPEEGLM 403
            |...||.:|.|..: |:||:.|.:...|:::||.:|||| |.:..|||.||.||||.:.|.:|..
Human   165 ECQTKYGNANAWRYCTKVFDMLTVAALIDEQILCVHGGL-SPDIKTLDQIRTIERNQEIPHKGAF 228

  Fly   404 CELLWSDPQQWMGLGQSKRGVGIQFGPDVTEKFCKDNNLDYIIRSHEVKDMGYEVAHNGKCITVF 468
            |:|:||||:.......|.||.|..||..||.:|...|||..|.|:|::...||:...:.|.:||:
Human   229 CDLVWSDPEDVDTWAISPRGAGWLFGAKVTNEFVHINNLKLICRAHQLVHEGYKFMFDEKLVTVW 293

  Fly   469 SAPNYCDTMGNMGAFITITG-NNLKPNYKSFEAVP 502
            ||||||...||:.:.:.... |..:|  |.|.|||
Human   294 SAPNYCYRCGNIASIMVFKDVNTREP--KLFRAVP 326

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PpD3	NP_001262433.1	TPR_11	49..114	CDD:290150
		TPR_1	49..81	CDD:278916
		TPR repeat	49..77	CDD:276809
		TPR repeat	82..112	CDD:276809
		MPP_PP5_C	198..513	CDD:277362	116/295 (39%)
		PP2Ac	226..502	CDD:197547	109/277 (39%)
PPP6C	NP_001116827.1	MPP_PP2A_PP4_PP6	5..326	CDD:277360	114/293 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0639
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810