DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PpD3 and CanA1

DIOPT Version :9

Sequence 1:	NP_001262433.1	Gene:	PpD3 / 49779	FlyBaseID:	FBgn0005777	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001247378.2	Gene:	CanA1 / 43670	FlyBaseID:	FBgn0010015	Length:	622	Species:	Drosophila melanogaster

Alignment Length:	385	Identity:	130/385 - (33%)
Similarity:	192/385 - (49%)	Gaps:	43/385 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 VAKCRPNDKDAKLKFTECNKIVKMRAFERAIAVDKPE----KTLSEMYSDM-----ENITIEDDY 198
            ::|...:||.||........       ..|.:.:|.:    ||...|..|:     ..:|:.:.|
  Fly    16 LSKSSSSDKSAKSSSNSSKS-------PTAASGNKQKMQYTKTRERMVDDVPLPPTHKLTMSEVY 73

  Fly   199 KGPQLEDGKVTLKFMKELMEHYKAQKRLHRKFAYKILCEIDTYMRAQPSLVDITVPDEEKFTICG 263
            ..|  :.||..   ...|.:|:..:.|:....|.:|:.|....:|.:.:::|:..|    .|:||
  Fly    74 DDP--KTGKPN---FDALRQHFLLEGRIEEAVALRIITEGAALLREEKNMIDVEAP----ITVCG 129

  Fly   264 DIHGQFYDLMNIFEINGLPSEKNPYLFNGDFVDRGSFSVECIFTLFGFKLLYPNHFFLARGNHES 328
            ||||||:||:.:||:.|.|:... |||.||:||||.||:||:..|:..|:.||....|.|||||.
  Fly   130 DIHGQFFDLVKLFEVGGPPATTR-YLFLGDYVDRGYFSIECVLYLWSLKITYPTTLSLLRGNHEC 193

  Fly   329 INMNQMYGFTGEVTAKYTSAMADIFTQVFNWLPLCHCINQKILVMHGGLFSTEDVTLDHIRRIER 393
            .::.:.:.|..|...||:.::.|...:.|:.|||...:||:.|.:|||| |.|..|||.|:.:.|
  Fly   194 RHLTEYFTFKQECIIKYSESIYDACMEAFDCLPLAALLNQQFLCIHGGL-SPEIFTLDDIKTLNR 257

  Fly   394 NCQPPEEGLMCELLWSDPQQWMG--------LGQSKRGVGIQFGPDVTEKFCKDNNLDYIIRSHE 450
            ..:||..|.||:||||||.:..|        ...|.||....|......:|.:.|||..|:|:||
  Fly   258 FREPPAYGPMCDLLWSDPLEDFGNEKTNEFFSHNSVRGCSYFFSYSACCEFLQKNNLLSIVRAHE 322

  Fly   451 VKDMGYEVAHNGK------CITVFSAPNYCDTMGNMGAFITITGNNLKPNYKSFEAVPHP 504
            .:|.||.:....:      .||:||||||.|...|..|.:....|.:  |.:.|...|||
  Fly   323 AQDAGYRMYRKNQVTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVM--NIRQFNCSPHP 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PpD3	NP_001262433.1	TPR_11	49..114	CDD:290150
		TPR_1	49..81	CDD:278916
		TPR repeat	49..77	CDD:276809
		TPR repeat	82..112	CDD:276809
		MPP_PP5_C	198..513	CDD:277362	118/321 (37%)
		PP2Ac	226..502	CDD:197547	108/289 (37%)
CanA1	NP_001247378.2	MPP_PP2B	81..385	CDD:277361	114/311 (37%)
CanA1	NP_001247378.2	PP2Ac	98..369	CDD:197547	106/276 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438828
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0639
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.830