DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PpD3 and Ppef1

DIOPT Version :9

Sequence 1:	NP_001262433.1	Gene:	PpD3 / 49779	FlyBaseID:	FBgn0005777	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	XP_038955765.1	Gene:	Ppef1 / 317498	RGDID:	1562772	Length:	664	Species:	Rattus norvegicus

Alignment Length:	472	Identity:	151/472 - (31%)
Similarity:	231/472 - (48%)	Gaps:	73/472 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 SAVKADPA--------YLKGYYRRAAAHMSLGKFKQALCDFEFVAKCRPNDKDAKLK-------- 156
            :::..||.        .::.:|||..|.:| .:...||..|:.:...   |:..:::
  Rat    30 ASITKDPGDLMVRAALIIQNWYRRYRARLS-ARQHYALAIFQSIEYA---DEQGQMQLSSFFSFM 90

  Fly   157 ---FTECNK---IVKMRAFERAIAVDKPEKTLSEMYSDMENITIEDDYKGPQLEDGKVTLKFMKE 215
               :|..:|   .:..|.||..    :.|....|.|..:  |.:.|.|.||:|: ..:|...:..
  Rat    91 LENYTNTHKEDSALVSRLFENT----RLESKDREEYVGL--IDVPDSYDGPRLQ-FPLTFTDINL 148

  Fly   216 LMEHYKAQKRLHRKFAYKILCEIDTYMRAQPSLVDITVPDEEKFTICGDIHGQFYDLMNIFEING 280
            |::.:|.|:.||..:..::|.|....::..|:...|.....::.|||||:||:..|||.||..||
  Rat   149 LLQAFKQQQTLHAHYVLEVLFEARKILKQMPNFTRIQTFPAKEITICGDLHGKLDDLMLIFYKNG 213

  Fly   281 LPSEKNPYLFNGDFVDRGSFSVECIFTLFGFKLLYPNHFFLARGNHESINMNQMYGFTGEVTAKY 345
            ||||||||:|||||||||:.|:|.:..|....|:||....|.|||||...||..||||.|:..||
  Rat   214 LPSEKNPYVFNGDFVDRGNNSMEILMILLVSFLVYPTDLHLNRGNHEDFMMNLRYGFTKEILQKY 278

  Fly   346 T---SAMADIFTQVFNWLPLCHCINQKILVMHGGLFSTEDVTLDHIRRIERN------------- 394
            .   ..:..:..:::.|||:...|:.:|||:|||:  :|...|:.:::::||
  Rat   279 KLHGKKILQVLEELYTWLPIGTIIDNEILVIHGGI--SESTDLNILQQLQRNKMKSVLMPPMSTN 341

  Fly   395 --CQ-------PPEEGL-----------MCELLWSDPQQWMG-LGQSKRGVGIQFGPDVTEKFCK 438
              |.       |.|:..           :.:||||||:...| ...:.||.|..||||||.|...
  Rat   342 QECNIKKNKAGPSEQSASEQLTKLEWEQIIDLLWSDPRGKKGCYPNTSRGGGCYFGPDVTSKVLN 406

  Fly   439 DNNLDYIIRSHEVKDMGYEVAHNGKCITVFSAPNYCDTMGNMGAFITITGNNLKPNYKSFEAVPH 503
            .|.|..:|||||.|..|||:.|:||.||||||.||.:...|.||:|.:: ....|.:..::....
  Rat   407 KNQLKMVIRSHECKPDGYEICHDGKVITVFSASNYYEEGSNRGAYIRLS-YGTSPQFFQYQVTST 470

  Fly   504 PDVKPMAYANSLMNWLA 520
            ..:.|:....:.|.:.|
  Rat   471 SCLNPLYQRVNAMEFSA 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PpD3	NP_001262433.1	TPR_11	49..114	CDD:290150	0/5 (0%)
		TPR_1	49..81	CDD:278916
		TPR repeat	49..77	CDD:276809
		TPR repeat	82..112	CDD:276809	0/3 (0%)
		MPP_PP5_C	198..513	CDD:277362	128/351 (36%)
		PP2Ac	226..502	CDD:197547	119/312 (38%)
Ppef1	XP_038955765.1	IQ	40..>57	CDD:197470	3/16 (19%)
		MPP_RdgC	140..466	CDD:277364	123/328 (38%)
		PTZ00183	505..647	CDD:185503
		EF-hand_7	582..650	CDD:404394
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0639
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D215218at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820